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The influence of lemon thyme in the phenolic composition and bioactive properties of medicinal and aromatic plants tisanes

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dc.contributor.authorPaschoalinotto, B.H.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorAlves, Maria José
dc.contributor.authorMocan, Andrei
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-02-01T11:37:24Z
dc.date.available2022-02-01T11:37:24Z
dc.date.issued2021
dc.description.abstractLemon thyme is used for cooking and normally consumed as an infusion, presenting antimicrobial, anti-inflammatory, and antioxidant potential[1]. However, the presence and importance of this specie in tisanes of medicinal and aromatic plants (MAP) for infusion preparation is little recognized. It is also known that mixtures of MAP show more favorable phenolic composition and bioactive properties then the individual plants[2]. For that, the present study aimed to characterize the phenolic composition by HPLC-DAD/ESI-MS of three tisanes prepared from MAP mixtures containing lemon thyme, as also study their bioactive properties, namely antioxidant, antimicrobial, anti-inflammatory, cytotoxic, and anti-diabetic activities. Thus, the tisane composed by lemon thyme, Shrubby St. John's Wort, cloves, and cinnamon, was the most promising mixture, presenting the lowest EC50, GI50, and IC50 values for theinhibition of the lipid peroxidation, anti-inflammatory/cytotoxicity against tumor cell line ofadenocarcinoma breast, and antidiabetic activity, respectively. In addition, it also showed thehighest concentration of phenolic acids (caffeoylquinic acids derivatives) and flavan-3-ols (catechin derivatives). For the anti-hemolytic and antimicrobial activities (Gram-negative bacteria), the mixture composed by lemon thyme, lavender, common thyme, and purple perennial showed the lowest IC50 and MIC (higher bioactive potential) values, respectively. Finally, the tisane containing lemon thyme, basil, peppermint, calendula, and rosemary proved to be the best mixture to inhibit the growth of the tumor cell lines HepG2, NCI H460 and HeLa The results obtained reinforce the principle of synergy between mixtures of MAP, making it possible to obtain promising sources of bioactive compounds with different phenolic profiles with high added value that can be applied in the pharmaceutical and food industry for the development of new functional products.pt_PT
dc.description.sponsorshipTo Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019); the national funding by FCT, P.I., through the institutional and individual scientific employment program-contract for L. Barros/M.I. Dias and J. Pinela contract (CEECIND/01011/2018), respectively; to FEDER-Interreg España-Portugal programme (TRANSCoLAB 0612_TRANS_CO_LAB_ 2_P). To Cantinho das Aromáticas company (tisane supplier).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPaschoalinotto, Beatriz H.; Dias, Maria Inês; Pinela, José; Pires, Tânia C.S.; Alves, Maria José; Mocan, Andrei; Calhelha, Ricardo C.; Ineu, Rafael P.; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). The influence of lemon thyme in the phenolic composition and bioactive properties of medicinal and aromatic plants tisanes. In 5th International Symposium on Phytochemicals in Medicine and Food. Nanchang, Chinapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/24984
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCEECIND/01011/2018/CP1578/CT0002
dc.relationMountain Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleThe influence of lemon thyme in the phenolic composition and bioactive properties of medicinal and aromatic plants tisanespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardNumberCEECIND/01011/2018/CP1578/CT0002
oaire.awardNumberUID/AGR/00690/2019
oaire.awardTitleCEECIND/01011/2018/CP1578/CT0002
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01011%2F2018%2FCP1578%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.citation.title5th International Symposium on Phytochemicals in Medicine and Foodpt_PT
oaire.fundingStreamCEEC IND 2018
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePaschoalinotto
person.familyNameDias
person.familyNamePinela
person.familyNamePires
person.familyNameAlves
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameBarros
person.givenNameBeatriz H.
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameTânia C.S.P.
person.givenNameMaria José
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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