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Deformation of red blood cells, air bubbles and droplets in microfluidic devices: flow visualizations and measurements

2018Journal article Open access
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dc.contributor.authorBento, David
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorFaustino, Vera
dc.contributor.authorPinho, Diana
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorPereira, Ana I.
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorMiranda, João Mário
dc.contributor.authorLima, Rui A.
dc.date.accessioned2020-02-27T15:24:16Z
dc.date.available2020-02-27T15:24:16Z
dc.date.issued2018
dc.description.abstractTechniques, such as micropipette aspiration and optical tweezers, are widely used to measure cell mechanical properties, but are generally labor-intensive and time-consuming, typically involving a difficult process of manipulation. In the past two decades, a large number of microfluidic devices have been developed due to the advantages they offer over other techniques, including transparency for direct optical access,lower cost, reduced space and labor, precise control, and easy manipulation of a small volume of blood samples. This review presents recent advances in the development of microfluidic devices to evaluate the mechanical response of individual red blood cells (RBCs) and microbubbles flowing in constriction microchannels.Visualizations and measurements of the deformation of RBCs flowing through hyperbolic,smooth,and sudden-contraction microchannels were evaluated and compared. In particular, we show the potential of using hyperbolic-shaped microchannels to precisely control and assess small changes in RBC deformability in both physiological and pathological situations. Moreover, deformations of air microbubbles and droplets flowing through a microfluidic constriction were also compared with RBCs deformability.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBento, David; Rodrigues, Raquel O.; Faustino, Vera; Pinho, Diana; Fernandes, Carla S.; Pereira, Ana I.; Garcia, Valdemar; Miranda, João M.; Lima, R. (2018). Deformation of red blood cells, air bubbles and droplets in microfluidic devices: flow visualizations and measurements. Micromachines. ISSN 2072-666X. 9:151pt_PT
dc.identifier.doi10.3390/mi9040151pt_PT
dc.identifier.issn2072-666X
dc.identifier.urihttp://hdl.handle.net/10198/20734
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRed blood cellspt_PT
dc.subjectDeformation indexpt_PT
dc.subjectMicrofluidic devicespt_PT
dc.subjectAir bubblespt_PT
dc.subjectDropletspt_PT
dc.subjectBloo dflowpt_PT
dc.titleDeformation of red blood cells, air bubbles and droplets in microfluidic devices: flow visualizations and measurementspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue151pt_PT
oaire.citation.titleMicromachinespt_PT
oaire.citation.volume9pt_PT
person.familyNamePinho
person.familyNameFernandes
person.familyNamePereira
person.familyNameGarcia
person.givenNameDiana
person.givenNameCarla S.
person.givenNameAna I.
person.givenNameValdemar
person.identifier.ciencia-id5214-ED0C-35E8
person.identifier.ciencia-idF319-3D67-9DB7
person.identifier.ciencia-id0716-B7C2-93E4
person.identifier.orcid0000-0002-3884-6496
person.identifier.orcid0000-0002-3138-7493
person.identifier.orcid0000-0003-3803-2043
person.identifier.orcid0000-0002-3941-2438
person.identifier.ridA-4269-2015
person.identifier.ridF-3168-2010
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id15071961600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication02bf2dd9-33ed-4d87-b61d-ca39c51f8451
relation.isAuthorOfPublication8f9cf139-cfef-4025-ba87-56425618bc6e
relation.isAuthorOfPublicatione9981d62-2a2b-4fef-b75e-c2a14b0e7846
relation.isAuthorOfPublicationf9422279-4412-49c2-becd-1e696a8c5c4b
relation.isAuthorOfPublication.latestForDiscoverye9981d62-2a2b-4fef-b75e-c2a14b0e7846

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