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Inhibitory activity of Coprinopsis atramentaria extract, organic acids and their possible methylated synthesized metabolites on growth of human tumor cell lines

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dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorMartins, Anabela
dc.contributor.authorQueiroz, Maria João R.P.
dc.date.accessioned2014-03-27T18:17:46Z
dc.date.available2014-03-27T18:17:46Z
dc.date.issued2013
dc.description.abstractCoprinopsis atramentaria (Bull.: Fr.) Redhead. Vilgalys & Moncalvo, is a wild edible mushroom previously characterized by our research group for its nutritional composition, and showed a notable antioxidant activity. p-Hydroxybenzoic (4. 71 mg/1 00 g dry weight), p coumaric (0.82 mg/ 100 g) and cinnamic (1.70 mg/100 g) acids were identified in its extract, but have been reported as common compounds in other mushrooms. In the present work, the inhibitory activity of the growth of human tumor cell lines MCF-7 (breast adenocarcinoma), NCl-H460 (non-small cell lung carcinoma), HCT 15 (colon carcinoma). 1-lcLa (cervical carcinoma) and l-l epG2 (hepatocellular carcinoma) and non-tumor porcine liver primary cell culture (PLP2). was evaluated by the sulforhodamine B assay', using C. atramentaria methanolic extract, the identified organic acids separately and their synthesized methylated possible metabolites, for MCF7, NCI-H460 and HCT 15 cell lines the extract presented high growth inhibitory activity with GI 50 values 53 .1 0±4.72. 15.13±1.35 and 36.44±3.30 pg/mL, respectively, and no activity on non tumor cells (GI 400 pg/mL). In most of the cases, methylated possible metabolites showed higher activity than the corresponding parental compounds. The substitution of the carboxylic group (in parental organic ac ids) for an ester increased the growth inhibitory activity of tumor cell lines not revealing any toxicity for non-tumor cells PLP2. Organic acids, mainly phenolic compounds, arc extensively metabolized in humans, being methylation one of the conjugated forms occurring in the organism and giving methylated metabolites. Therefore the present study contributes to understand the bioactivity of organic acids and derivative compounds. including human possible metabolites.por
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT , Portugal) for financial support to the Portuguese NMR network and to FCT and FEDER-COMPETE/QREN/EU for the financial support through the research project PTDC/AGR-ALI/ 110062/2009 and the research centres ( PEst-C/QUI/U10686/2011 and PEstOE/ AGR/U101690/2011). S.A. Heleno (BD/70304/2010) and R.C. Calhelha (BPD/68344/2010) also thank FCT, POPH-QREN and FSE.por
dc.identifier.citationHeleno, Sandrina A.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Martins, Anabela; Queiroz, Maria-João R. P. (2013). Inhibitory activity of Coprinopsis atramentaria extract, organic acids and their possible methylated synthesized metabolites on growth of human tumor cell lines. In XIX Encontro Galego-Português de Química. Vigopor
dc.identifier.isbn978-84-695-8688-4
dc.identifier.urihttp://hdl.handle.net/10198/9401
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPEst-C/QUI/U10686/2011
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
dc.titleInhibitory activity of Coprinopsis atramentaria extract, organic acids and their possible methylated synthesized metabolites on growth of human tumor cell linespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleIMPORTANT HUMAN METABOLITES OF PHENOLIC ACIDS FROM DIET WITH WILD EDIBLE MUSHROOMS: CHEMICAL SYNTHESIS AND STUDIES OF THEIR ANTIOXIDANT AND ANTITUMOR PROPERTIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70304%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceVigo, Espanhapor
oaire.citation.titleXIX Encontro Galego-Português de Químicapor
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamSFRH
person.familyNameHeleno
person.familyNameFerreira
person.familyNameCalhelha
person.familyNameMartins
person.givenNameSandrina A.
person.givenNameIsabel C.F.R.
person.givenNameRicardo C.
person.givenNameAnabela
person.identifier144781
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-id9418-CF95-9919
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person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-6218-4413
person.identifier.ridL-5951-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-2172-2014
person.identifier.ridG-5488-2013
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id7203013518
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
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