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Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies

2017Journal article Open access
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dc.contributor.authorRodrigues, Ana Rita O.
dc.contributor.authorAlmeida, Bernardo G.
dc.contributor.authorRodrigues, Juliana M.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorPires, A.
dc.contributor.authorPereira, André M.
dc.contributor.authorAraújo, José Pedro
dc.contributor.authorCoutinho, Paulo J.G.
dc.contributor.authorCastanheira, Elisabete M.S.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T14:59:59Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T14:59:59Z
dc.date.issued2017
dc.description.abstractMagnetoliposomes containing superparamagnetic manganese ferrite nanoparticles were tested as nanocarriers for two new promising antitumor drugs, a N-(3-methoxyphenyl)thieno[3,2-b]pyridin-7-amine (1) and a N-(2-methoxy-phenyl)thieno[3,2-b] pyridin-7-amine (2). The fluorescence emission of both compounds was studied in different polar and non-polar media, evidencing a strong intramolecular charge transfer character of the excited state of both compounds. These in vitro potent antitumor thienopyridine derivatives were successfully incorporated in both aqueous and solid magnetoliposomes, with encapsulation efficiencies higher than 75%. The magnetic properties of magnetoliposomes containing manganese ferrite nanoparticles were measured for the first time, proving a superparamagnetic behaviour. Growth inhibition assays on several human tumor cell lines showed very low GI 50 values for drug-loaded aqueous magnetoliposomes, comparing in most cell lines with the ones previously obtained using the neat compounds. These results are important for future drug delivery applications using magnetoliposomes in oncology, through a dual therapeutic approach (simultaneous chemotherapy and magnetic hyperthermia).pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013), CQUM (UID/QUI/00686/2013 and 2016) and CIMO (UID/AGR/00690/ 2013), the latter also supported by FEDER – Program PT2020. FCT, POPH-QREN and FSE are acknowledged for the PhD grant of A. R. O. Rodrigues (SFRH/BD/90949/2012), the postdoc grant of R. C. Calhelha (SFRH/BPD/68344/2010) and for nancial support to MAP-Fis PhD Programme.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, Ana Rita O.; Almeida, B. G.; Rodrigues, Juliana M.; Queiroz, Maria João R.P.; Calhelha, R. C.; Ferreira, Isabel C.F.R.; Pires, A.; Pereira, A. M.; Araújo, J. P.; Coutinho, Paulo J.G.; Castanheira, Elisabete M.S. (2017). Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies. RSC Advances. ISSN 2046-2069. 7, p. 15352-15361en_EN
dc.identifier.doi10.1039/c7ra00447hpt_PT
dc.identifier.urihttp://hdl.handle.net/10198/15262
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationUID/QUI/00686/2016
dc.relationChemistry Research Centre of the University of Minho
dc.relationMAGNETOLIPOSSOMAS DE NANOPARTÍCULAS BASEADAS EM NÍQUEL PARA ENTREGA DE POTENCIAIS FÁRMACOS ANTITUMORAIS
dc.titleMagnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studiesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemistry Research Centre of the University of Minho
oaire.awardTitleMAGNETOLIPOSSOMAS DE NANOPARTÍCULAS BASEADAS EM NÍQUEL PARA ENTREGA DE POTENCIAIS FÁRMACOS ANTITUMORAIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FFIS%2F04650%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00686%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F90949%2F2012/PT
oaire.fundingStreamSFRH
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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