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Bioactivity of Chenopodium ambrosioides L.: antioxidant and antitumour potential, and detailed characterization in bioactive compounds

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dc.contributor.authorBarros, Lillian
dc.contributor.authorPereira, Eliana
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-09T13:51:19Z
dc.date.available2013-09-09T13:51:19Z
dc.date.issued2013
dc.description.abstractMedicinal plants are recognized as important sources of novel biomolecules, which theoretically can be used in the treatment of diverse diseases. Chenopodium ambrosioides L. (Amaranthaceae; syn: Dysphania ambrosioides (L.) Mosyakin & Clemants) is an example of a plant formerly used in Portuguese traditional medicine, normally consumed as infusion of its dried leaves and flowering stems. lt has diverse pharmacological applications in the treatment of influenza, cold or gastrointestinal and respiratory ailments, healing of skin ulceration caused by Leishmania species, as well as vomitive, antihelmintic, anti-inflammatory and antitumor properties [1-3]. In this study, the bioactive properties (antioxidant and antitumour activities, and hepatotoxicity) of the infusion and methanolic extract of wild C. ambrosioides were evaluated and compared. Furthermore, the chemical composition in hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) compounds were determined. In general, the infusion revealed higher antioxidant activity, while the methanolic extract was the only one showing antitumour effects against colon, cervical and hepatocellular carcinoma cell lines. No toxicity in non-tumour cells was observed either for the infusion or the extract. Bioactive compounds such as some sugars and organic acids, phenolic compounds, unsaturated fatty acids and tocopherols were identified and quantified in C. ambrosioides. As far as we know, this is the first detailed chemical characterization and bioactivity evaluation of C. ambrosioides methanolic extract and infusion.por
dc.description.sponsorshipFundação para a Ciencia e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011 ). L. Barros also thanks to FCT, POPH-QREN and FSE for her grant (SFRH/BPD/4609/2008). The GIP-USAL is financially supported by the Spanish Government through the Consolider-lngenio 2010 Programme (FUN-CFOOD, CSD2007-00063). M. Duenas thanks to the Programa Ram6n y Cajal tor a contract.por
dc.identifier.citationBarros, Lillian; Pereira, Eliana; Dueñas, Montserrat; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2013). Bioactivity of Chenopodium ambrosioides L.: antioxidant and antitumour potential, and detailed characterization in bioactive compounds. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8678
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleBioactivity of Chenopodium ambrosioides L.: antioxidant and antitumour potential, and detailed characterization in bioactive compoundspor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.familyNamePereira
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameEliana
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idBE17-462D-9A75
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-2854-6745
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridQ-8017-2018
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id55938912300
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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