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Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: chemical, toxicological and bioactivities characterization

2021Journal article Open access
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dc.contributor.authorSemaoui, Redouane
dc.contributor.authorOuafi, Saida
dc.contributor.authorMachado, Susana
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorOliveira, Beatriz
dc.date.accessioned2021-08-05T13:54:13Z
dc.date.available2021-08-05T13:54:13Z
dc.date.issued2021
dc.description.abstractEthnopharmacological relevance: Salvia chudaei Batt. & Trab. from Algeria is traditionally used to relieve several dysfunctions, including inflammatory and pain-related situations. Aim of the study: This work aimed to confirm scientifically the referred properties. For that, the phenolic composition and antioxidant activity were evaluated as well as acute toxicity, anti-inflammatory and analgesic effects of different doses of the infusion of S. chudaei aerial parts. Materials and methods: Infusion of aerial parts of S. chudaei was prepared and screened for phenolic composition by generalized methods TPC and TFC then by LCDAD- ESI/MSn. DPPH and FRAP were used to evaluate antioxidant activity. Using mice, acute toxicity, anti-inflammatory by carrageenan-induced paw edema, and analgesic by acetic acid-induced writhing and formalin-induced pain activities were tested. Results: The infusion showed 2018 mg GAE/100g DW of phenolics and 1956 mg ECE/100g DW of flavonoids. Phenolic profile by LC-DAD-ESI/MSn revealed the presence of ten compounds: syringic acid hexoside derivative, kaempferol-O-diglucuronide, kaempferol-O-deoxyhexoside-hexoside, kaempferol-O-glucuronide, apigenin-O-diglucuronide, caffeic acid, 4-O-caffeoylquinic acid, eriodictyol-O-glucuronide, rosmarinic acid hexoside, and rosmarinic acid. This acid was the major compound representing 54% of the total content of the identified compounds and an absolute content of 18 mg/g of extract. Additionally, the infusion exhibited a good antioxidant activity (DPPH: 81 μmol TE/g DW, FRAP: 438 μmol FSE/g DW). By oral administration to mice, the infusion showed a significant (p<0.05) dose-dependent reduction of carrageenan-induced inflammation and inhibition of formalin-induced pain (late and early phase) and acetic acid-induced writhing compared with the control. On the other hand, infusion up to 8 g/kg b.w. showed no signs of toxicity or mortality. Conclusion: This study reveals, for the first time, that the infusion of the aerial parts of S. chudaei is not toxic in a single dose and has remarkable antioxidant, antiinflammatory, and analgesic activities, supporting the use of this species in folk medicine.pt_PT
dc.description.sponsorshipWe thank the University of Porto for receiving R.S. and the MARE NOSTRUM 2017–2019 project allowing this mobility. This work was supported by AgriFood XXI I&D&I project (NORTE-01-0145-FEDER- 000041) co-financed by ERDF through NORTE 2020 (Programa Operacional Regional do Norte 2014/2020), by the UIDB/50006/2020 project with funding from FCT/MCTES through Portuguese funds, by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to CIMO (UIDB/00690/2020), and by the Ministry of Higher Education and Scientific Research (MESRS) (Algeria).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSemaoui, Redouane; Ouafi, Saida; Machado, Susana; Barros, Lillian; Ferreira, Isabel C.F.R.; Oliveira, Beatriz (2021). Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: chemical, toxicological and bioactivities characterization. Journal of Ethnopharmacology. ISSN 0378-8741. 280, p. 1-8pt_PT
dc.identifier.doi10.1016/j.jep.2021.114455pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10198/23802
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSalvia chudaei Batt. & Trab.pt_PT
dc.subjectInfusionpt_PT
dc.subjectAlgeriapt_PT
dc.titleInfusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: chemical, toxicological and bioactivities characterizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage114455pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume280pt_PT
person.familyNameBarros
person.familyNameFerreira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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