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Development of semi-solid formulations containing Juglans regia L. leaves extracts for tropical application

2021Conference object Open access
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dc.contributor.authorBesrour, Nermine
dc.contributor.authorChammakhi, Yosra
dc.contributor.authorPinela, José
dc.contributor.authorMezni, Mohamed
dc.contributor.authorCaleja, Cristina
dc.contributor.authorPereira, Carla
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorAlves, Maria José
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Olga
dc.date.accessioned2022-02-04T16:23:30Z
dc.date.available2022-02-04T16:23:30Z
dc.date.issued2021
dc.description.abstractNowadays, cosmetic brands are urged to follow sustainable development strategies via circular economy and low carbon footprint processes. Using ingredients from agri-food waste to generate new cosmetic products and environmentally friendly solvents are one of the paths to meet those challenges [1]. In this regard, glycerol and alkanediols can be seen as alternative solvents to extract phytochemicals from plant material due to their potential application in the cosmetics area. In this work, the leaves of walnut trees (Juglans regia L.) were studied as a source of bioactive compounds. Their extracts are already used in traditional herbal medicine but can be further valorised as potential bioactive ingredients in the cosmeceutical area. The extracts were obtained using aqueous solutions of ethanol or 1,2-propanediol, and diverse bioactivity studies (antioxidant, cytotoxic, anti-inflammatory, antimicrobial, anti-tyrosinase, and photostability) were carried out. Better results were obtained with the hydroethanolic extracts in the anti-tyrosinase, antioxidant, and anti-inflammatory dimensions. In the antimicrobial assay, both extracts showed similar microbial properties. The main phytochemicals identified in both extracts were 3-O-caffeoylquinic acid, quercetin-O-pentoside, taxifolin-O-pentoside isomer, quercetin 3-O-glucoside, and 3-p-coumaroylquinic acid. After, the propanediol and hydroethanolic extracts were incorporated in a commercial base cream, aiming to design a formulation for topical application. The following parameters were studied to evaluate the stability of the final formulation: pH, colour, phenolic compounds content, and antioxidant activity. The formulation containing the hydroethanolic extract was the best to conserve the identified phenolic compounds for 30 days, at different temperature conditions (5 ºC, 20 ºC, and 40 ºC). The formulation containing the propanediol extract should be redesigned by incorporating higher amounts of extract. Both formulations presented relevant antioxidant activity and a favourable pH range of 3.8 to 4.7. These preliminary results suggest the potential application of J. regia extracts as an ingredient for incorporation into skin care products as they showed a very satisfactory chemical and physical stability at the studied time and temperature storage conditions. Nevertheless, additional studies will be performed not only to evaluate their stability over longer periods of time, but also their safety and toxicity.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and national funding by FCT, P.I., through the institutional and individual scientific employment program-contract for C. Pereira, L. Barros, and J. Pinela (CEECIND/01011/2018), respectively. This work was developed within the scope of the project AllNat (reference POCI-01-0145-FEDER-030463, PTDC/EQU-EPQ/30463/2017), funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI), Portugal 2020 and by national funds through FCT/MCTES. O. Taofiq and C. Caleja are grateful to the Project Mobilizador Norte-01-0247-FEDER-024479: ValorNatural® and POCI-01-0145-FEDER-030463: AllNat for their contracts.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationBesrour, Nermine; Chammakhi, Yosra; Pinela, José; Mezni, Mohamed; Caleja, Cristina; Pereira, Carla; Abreu, Rui M.V.; Alves, Maria José; Taofiq, Oludemi; Barros, Lillian; Ferreira, Olga (2021). Development of semi-solid formulations containing Juglans regia L. leaves extracts for tropical application. In 7th Portuguese Young Chemistry Meeting. ISBN 978-989-8124-31-0pt_PT
dc.identifier.isbn978-989-8124-31-0
dc.identifier.urihttp://hdl.handle.net/10198/25019
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCEECIND/01011/2018)pt_PT
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectJuglans regia L.pt_PT
dc.titleDevelopment of semi-solid formulations containing Juglans regia L. leaves extracts for tropical applicationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEQU-EPQ%2F30463%2F2017/PT
oaire.citation.conferencePlaceonline editionpt_PT
oaire.citation.title7º PYCheM- Portuguese Yuong Chemists Mettingpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
person.familyNamePinela
person.familyNameCaleja
person.familyNamePereira
person.familyNameAbreu
person.familyNameAlves
person.familyNameBarros
person.familyNameFerreira
person.givenNameJosé
person.givenNameCristina
person.givenNameCarla
person.givenNameRui M.V.
person.givenNameMaria José
person.givenNameLillian
person.givenNameOlga
person.identifier1415151
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person.identifier.orcid0000-0001-8414-3479
person.identifier.ridB-4466-2014
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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