Publication
Ultrasonographic evaluation of the kidney in 5/6 nephrectomized rats: Correlation with biochemical and histopathological findings
| dc.contributor.author | Nogueira, António José M. | |
| dc.contributor.author | Rocha, Ana Isabel Faustino | |
| dc.contributor.author | Ginja, Mário | |
| dc.contributor.author | Oliveira, Paula A. | |
| dc.contributor.author | Pires, Maria João | |
| dc.date.accessioned | 2018-01-31T10:00:00Z | |
| dc.date.accessioned | 2018-01-31T15:40:36Z | |
| dc.date.available | 2018-01-31T10:00:00Z | |
| dc.date.available | 2018-01-31T15:40:36Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | To characterize the kidney alterations associated with renal mass reduction by two-dimensional ultrasound and assess the correlation of the ultrasonographic parameters with the histological and biochemical findings. Materials and Methods: Rats were divided into two groups: sham-operated animals (n=13), and animals which underwent renal mass reduction (RMR) through 5/6 nephrectomy (n=14). Renal length, renal thickness, cortical thickness, medullary length and echogenicity of the kidneys were evaluated by ultrasonography at 3 and 6 months after the RMR. Results: Except for the renal length, the renal dimensions at 3 and 6 months were significantly higher in the RMR group when compared to the sham-operated group (p < 0.05). Furthermore, the cortical and medullary echogenicity was significantly higher in the RMR group when compared to the sham-operated group (p < 0.05). A significant correlation was observed between the plasma creatinine level and the renal length 3 months after RMR (r=-0.612, p=0.045). Conclusion: These data support future application of ultrasonography for monitoring the progression of renal damage in chronic studies with the 5/6 nephrectomy model. | en_EN |
| dc.description.sponsorship | This work was supported by : European Investment Funds by FEDER/COMPETE/POCI Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT – the Portuguese Foundation for Science and Technology, under project UID/AGR/04033/2013; and by European Investment Funds by FEDER/COMPETE/POCI Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER-016728 and National Funds by FCT – the Portuguese Foundation for Science and Technology, under the project PTDC/DTP-DES/6077/2014. | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | en_EN |
| dc.identifier.citation | Nogueira, António; Faustino Rocha, Ana; Ginja, Mario; Oliveira, Paula Alexandra; Pires, Maria João (2016). Ultrasonographic evaluation of the kidney in 5/6 nephrectomized rats: Correlation with biochemical and histopathological findings. In Vivo. ISSN 0258-851X. 30, p. 829-834 | en_EN |
| dc.identifier.doi | 10.21873/invivo.11001 | en_EN |
| dc.identifier.issn | 0258-851X | |
| dc.identifier.uri | http://hdl.handle.net/10198/15366 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | en_EN |
| dc.relation | POCI-01-0145-FEDER-016728 | |
| dc.subject | 5/6 nephrectomy model | en_EN |
| dc.subject | Echogenicity | en_EN |
| dc.subject | Kidney size | en_EN |
| dc.subject | Ultrasonography | en_EN |
| dc.subject | Wistar rats | en_EN |
| dc.title | Ultrasonographic evaluation of the kidney in 5/6 nephrectomized rats: Correlation with biochemical and histopathological findings | en_EN |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F04033%2F2013/PT | |
| oaire.fundingStream | 5876 | |
| person.familyName | Nogueira | |
| person.givenName | António José M. | |
| person.identifier.ciencia-id | 8A11-794E-36BD | |
| person.identifier.orcid | 0000-0001-8912-7355 | |
| person.identifier.scopus-author-id | 55865568268 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | en_EN |
| rcaap.type | article | en_EN |
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