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Multifunctional graphene-based magnetic nanocarriers optimized with copolymer Pluronic F127 for biomedical applications

2017Conference object Open access
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dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorBaldi, Giovanni
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSilva, Adrián
dc.contributor.authorLima, Rui A.
dc.contributor.authorGomes, Helder
dc.date.accessioned2020-01-15T11:45:47Z
dc.date.available2020-01-15T11:45:47Z
dc.date.issued2017
dc.description.abstractThe limitations of current cancer therapies prompt the urgent need for a more effective therapeutic strategy [1]. Graphene-based magnetic nanoparticles (GbMNPs) due to their unique properties, such as high chemical and thermal stability, high charge carrier mobility, large surface area for functionalization and superparamagnetic properties, have the potentiality to be used as efficient multifunctional nanocarrier systems [2]. However, one of the challenges of GbMNPs in biomedical applications is their tendency for agglomeration or precipitation in electrolyte solutions, such as those of body fluids [3]. To overcome this drawback, the developed GbMNPs were grafted with copolymer Pluronic F127 (PF127), yielding the materials denoted as GbMNPs@PF127. PF127 is a water-soluble and biocompatible triblock copolymer (PEO100-PPO65-PEO100) approved by the U.S. Food and Drug Administration (FDA) for use as food additive and in pharmaceutical formulations [4]. This grafting strategy allows the incorporation of a hydrophilic corona that reduces the aggregation of nanoparticles and the adsorption of blood proteins [4, 5]. Also, increases the biocompatibility of the nanosystems and its colloidal stability, prolonging blood circulation [5]. In this study, GbMNPs@PF127 were covalently conjugated with Doxorubicin (DOX), a highly effective chemotherapeutic drug against a broad spectrum of cancers. The developed therapeutic nanosystems were characterized and investigated to be used as multifunctional nanocarriers to combine thermo-chemotherapy, revealing exceptional features, such as: (i) high loading of the chemotherapeutic drug DOX; (ii) high pH stimuli-responsive controlled release; (iii) high heating efficiency profile under AMF with thermo-responsive drug release; as well as (iv) good haem- and biocompatibility even at high concentrations. The presented strategy and findings can represent a new way to design and synthesize highly stable graphene-based materials with novel structures for synergetic thermo-chemotherapy triggered by the abnormal cell microenvironment for a more effective treatment of cancer.pt_PT
dc.description.sponsorshipThis work was financially supported by: Project POCI-01-0145-FEDER-006984 Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) - and by nationalfunds through FCT - Fundação para a Ciência e Tecnologia R.O.R. acknowledgs the PHD scholarship SFRH/BD/97658/2013 granted by FCT. A.M.T.S. acknowledges the FCT Investigator 2013 Programme (IF/01501/2013), with financing from the European Social Fund and the Human Potential Operational Programme.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, Raquel; Baldi, Giovanni; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Silva, Adrián; Lima, Rui; Gomes, Helder (2017). Multifunctional graphene-based magnetic nanocarriers optimized with copolymer Pluronic F127 for biomedical applications. In XXIII Encontro Galego Português de Química. Ferrol. ISBN 978-84-697-7356-7pt_PT
dc.identifier.isbn978-84-697-7356-7
dc.identifier.urihttp://hdl.handle.net/10198/20385
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.titleMultifunctional graphene-based magnetic nanocarriers optimized with copolymer Pluronic F127 for biomedical applicationspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMAGNETIC CARBON NANOSTRUCTURES AND STUDY OF THEIR TRANSPORT IN MICROFLUIDIC DEVICES FOR HYPERTHERMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97658%2F2013/PT
oaire.citation.conferencePlaceFerrol, Espanhapt_PT
oaire.citation.startPage257pt_PT
oaire.citation.titleXXIII Encontro Galego-Portugués de Químicapt_PT
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameLima
person.familyNameGomes
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameRui A.
person.givenNameHelder
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0003-3428-637X
person.identifier.orcid0000-0001-6898-2408
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
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