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Unraveling the bioactive potential of grape pomace using deep eutectic solvents (DES)

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPérez-Pérez, Alba
dc.contributor.authorAlvaredo-López-Vizcaíno, Adela
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorFinimundy, Tiane C.
dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorDel-Río, Pablo G.
dc.contributor.authorGullón, Beatriz
dc.date.accessioned2026-07-08T14:48:22Z
dc.date.available2026-07-08T14:48:22Z
dc.date.issued2026
dc.description.abstractGrape pomace (GP) is the main by-product generated by the winemaking industry. Traditionally, the economic potential of this residue has been underestimated; however, it has recently attracted increasing interest as a promising source of high-value compounds. In this work, three deep eutectic solvents (DES) were assessed as green alternatives for the efficient extraction of phenolic compounds from GP. Amongst the tested solvents, the DES composed of choline chloride, acetic acid, and water (1:1:10 M ratio) showed the best performance. Under optimized extraction conditions (14.86 mL/g liquid-to-solid ratio (LSR), 60 °C, and 275.85 min), the total phenolic content (TPC) reached 113.71 mg GAE/g, while the condensed tannins content (CTC) was 125.37 mg CE/g. Antioxidant activity values were 165.25 mg TE/g for DPPH, 171.48 mg TE/g for ABTS, 102.88 mg TE/g for FRAP, and 367.79 mg TE/g for CUPRAC. Additionally, lipid peroxidation inhibition (TBARS) showed an IC50 of 337.02 μg/mL. HPLC-MS-ESI analysis of the optimal extract allowed the tentative identification of 18 phenolic compounds, mainly including phenolic acids, flavan-3-ols, anthocyanins, and tannins. Furthermore, the extract exhibited cytotoxic potential against gastrointestinal and liver cell lines with IC50 of 23 and 12 μg/mL, respectively; and antibacterial activity against Escherichia coli, Listeria monocytogenes, and methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) value of 33.35 mg/mL for all three bacterial strains. Overall, this study highlights red GP as a promising wine industry by-product for the recovery of bioactive compounds, although further studies are required to assess their safety and potential use as multifunctional ingredients.eng
dc.description.sponsorshipAuthors acknowledge (i) University of Vigo and CISUG for financing Open Access publication, (ii) Ministry of Science and Innovation of Spain (VALWIDE project TED2021–132088B-I00 and AdChemFood project PID2022-138458OB-I00) and Interreg VI-B Sudoe 2021-2027 (NEWPOWER, S1/1.1/E0116) for funding, and (iii) Consellería de Cultura, Educación e Ordenación Universitaria (Xunta de Galicia) through the contract ED431B 2025/34 to group Bio2Val as Group with Growth Potential, programs partially funded by ERDF. Alba Pérez-Pérez (FPU21/02446) acknowledge funding from Ministry of Universities of Spain. Pablo G. Del-Río acknowledges funding from Consellería de Cultura, Educación, Formación Profesional e Universidades (Xunta de Galicia) (ED481D-2025/008). Authors acknowledge Servicio de Seguridad Alimentaria y Desarrollo Sostenible from Centro de Apoio Científico e Tecnolóxico a Investigación (CACTI-Universidade de Vigo) for the use of scientific and technical services. This work was also supported by national funds through FCT/MCTES (PIDDAC): CIMO, UID/00690/2025 (10.54499/UID/00690/2025) and UID/PRR/00690/2025 (10.54499/UID/PRR/00690/2025); and SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020); and national funding by FCT, P.I., through the institutional scientific employment program contract for L.Barros (CEEC-INST, DOI: 10.54499/CEECINST/00107/2021/CP2793/CT0002) and the research contract of F. Mandim through the project 20651_DiVina – NORTE2030-FEDER-02089700.
dc.identifier.citationPérez-Pérez, Alba; Alvaredo-López-Vizcaíno, Adela; Pires, Tânia C.S.P.; Finimundy, Tiane C.; Mandim, Filipa; Barros, Lillian; Del-Río, Pablo G.; Gullón, Beatriz (2026). Unraveling the bioactive potential of grape pomace using deep eutectic solvents (DES). Biomass and Bioenergy. ISSN 0961-9534. 215, p. 1-14
dc.identifier.doi10.1016/j.biombioe.2026.109634
dc.identifier.issn0961-9534
dc.identifier.urihttp://hdl.handle.net/10198/36989
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMountain Research Center - UID/00690/2025
dc.relationCIMO - Mountain Research Center - UID/PRR/00690/2025
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
dc.relationInvestigação em alimentos e soluções de base biológica - CEECINST/00107/2021/CP2793/CT0002
dc.relationDiVina – Estratégia de valorização de dióspiros para o setor dos vinagres - 20651_DiVina | NORTE2030-FEDER-02089700
dc.relation.ispartofBiomass and Bioenergy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntioxidants
dc.subjectBox-Behnken design
dc.subjectBy-products
dc.subjectGrape bagasse
dc.subjectGreen solvents
dc.subjectPolyphenols
dc.titleUnraveling the bioactive potential of grape pomace using deep eutectic solvents (DES)eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/00690/2025
oaire.awardNumberUID/PRR/00690/2025
oaire.awardNumberLA/P/0007/2020
oaire.awardNumberCEECINST/00107/2021/CP2793/CT0002
oaire.awardNumber20651
oaire.awardTitleMountain Research Center - UID/00690/2025
oaire.awardTitleCIMO - Mountain Research Center - UID/PRR/00690/2025
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
oaire.awardTitleInvestigação em alimentos e soluções de base biológica - CEECINST/00107/2021/CP2793/CT0002
oaire.awardTitleDiVina – Estratégia de valorização de dióspiros para o setor dos vinagres - 20651_DiVina | NORTE2030-FEDER-02089700
oaire.awardURIhttp://hdl.handle.net/10198/35759
oaire.awardURIhttp://hdl.handle.net/10198/36356
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIhttps://doi.org/10.54499/CEECINST/00107/2021/CP2793/CT0002
oaire.awardURIhttps://morecolab.pt/projecto-divina/
oaire.citation.endPage14
oaire.citation.startPage1
oaire.citation.titleBiomass & Bioenergy
oaire.citation.volume215
oaire.fundingStreamCIMO
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamNORTE2030-FEDER-02089700
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
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project.funder.nameFundação para a Ciência e a Tecnologia
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