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Bioactive properties of Ruscus aculeatus L.: na underexploited subshrub

2021Documento de conferência Acesso aberto
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dc.contributor.authorRodrigues, Joana P.B.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPereira, Carla
dc.contributor.authorPires, Tânia C.S.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2022-02-01T11:07:44Z
dc.date.available2022-02-01T11:07:44Z
dc.date.issued2021
dc.description.abstractRuscus aculeatus L. is a sub-shrub used in traditional medicine in different parts of the world, namely in Europe and the Iberian Peninsula[1]. Traditionally, the aerial parts are mainly used as diuretics and the underground parts are used for the treatment of urinary tract diseases and as a laxative[2]. In the present work, the aerial part, roots, and rhizomes of R. aculeatus were characterized regarding their bioactive properties in order to contribute to the knowledge of the chemical composition of this unexplored species. The plant material of R. aculeatus was harvested in April 2019 inside woodlands and hedgerows, in Valpaços, Portugal. Two distinct parts were gathered: the aerial part (cladodes or laminar stems and lateral branches) and the underground organs (rhizomes with roots). Hydroethanolic extracts and aqueous (infusions and decoctions) preparations from the two mentioned parts of the plant were prepared. Multi-resistant clinical bacterial strains (Enterococcus faecalis, Listeria monocytogenes, methicillin-resistant Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Morganela morganii, Proteus mirabilis and Pseudomonas aeruginosa) were used to screen the antimicrobial activity and the antioxidant activity was evaluated through two different in vitro assays: inhibition of lipid peroxidation in brain homogenates by thiobarbituric acid reactive substances (TBARS) and oxidative hemolysis inhibition assay (OxHLIA). The cytotoxic activity was assayed using MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung carcinoma), HeLa (cervical carcinoma) and HepG2 (hepatocellular carcinoma) human tumor cell lines, and also a non-tumor cell line (porcine liver primary cells, PLP2). All extracts revealed antioxidant activity and potential to inhibit some of the assessed bacteria; except for the infusion of the aerial part (for the lines MCF7 and HepG2) and decoction extracts (line MCF7), all the remaining extracts presented effective results in the inhibition of the tested cell lines; the aqueous extracts of the aerial part and infusions of roots and rhizomes did not show cytotoxic effects in a non-tumor primary cell culture. This preliminary study provided innovative and interesting results in relation to the bioactive properties of this little-studied and explored wild plant.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020) and national funding by FCT, P.I., through the institutional scientific employment program-contract for L. Barros, A. Fernandes, C. Pereira and R.C. Calhelha´s contract. The authors are grateful to the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Norte-01-0145-FEDER-000042: GreenHealth.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, Joana P.B.; Fernandes, Ângela; Dias, Maria Inês; Pereira, Carla; Pires, Tânia C.S.; Calhelha, Ricardo C.; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Bioactive properties of Ruscus aculeatus L.: na underexploited subshrub. In 5th International Symposium on Phytochemicals in Medicine and Food. Nanchang, Chinapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/24982
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRuscus aculeatus L.pt_PT
dc.subjectTraditional medicinept_PT
dc.titleBioactive properties of Ruscus aculeatus L.: na underexploited subshrubpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.title5th International Symposium on Phytochemicals in Medicine and Foodpt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRodrigues
person.familyNameFernandes
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person.familyNamePereira
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person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.familyNameBarros
person.givenNameJoana P. B.
person.givenNameÂngela
person.givenNameMaria Inês
person.givenNameCarla
person.givenNameTânia C.S.P.
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.givenNameLillian
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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