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Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16

2020Artigo científico Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Biotecnologia Industrial
datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorLeite, Natasha Rios
dc.contributor.authorAraújo, Laura Costa Alves
dc.contributor.authorRocha, Paola dos Santos
dc.contributor.authorAgarrayua, Danielle Araujo
dc.contributor.authorÁvila, Daiana Silva
dc.contributor.authorCarollo, Carlos Alexandre
dc.contributor.authorSilva, Denise Brentan
dc.contributor.authorEstevinho, Letícia M.
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authorSantos, Edson Lucas dos
dc.date.accessioned2026-07-02T10:26:21Z
dc.date.available2026-07-02T10:26:21Z
dc.date.issued2020
dc.description.abstractFruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit Dipteryx alata; evaluate its toxic effects, influence on the life expectancy of the nematode Caenorhabditis elegans, and its antioxidant activities in vitro and in vivo; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The in vitro antioxidant activity was demonstrated by radical scavenging methods. in vivo, the D. alata fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan of C. elegans. These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and/or nutraceutical food.eng
dc.description.sponsorshipThis study was supported by grants from the Fundação de Apoio ao Desenvolvimento do Ensino,Ciência e Tecnologia do Mato Grosso do Sul (FUNDECT), Conselho Nacional de Desenvolvimento Cientıfico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Financiadora de Estudos e Projetos (Finep) and Pró-Reitoria de Ensino de Pós-Graduação e Pesquisa da UFGD (PROPP-UFGD).
dc.identifier.citationLeite, Natasha Rios; Araújo, Laura Costa Alves de; Rocha, Paola dos Santos; Agarrayua, Danielle Araujo; Ávila, Daiana Silva; Carollo, Carlos Alexandre; Silva, Denise Brentan; Estevinho, Leticia M.; Souza, Kely de Picoli; Santos, Edson Lucas dos (2020). Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16. Biomolecules. ISSN 2218-273X. 10:8, p. 1-22
dc.identifier.doi10.3390/biom10081106
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/10198/36967
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofBiomolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntioxidant
dc.subjectC. elegans
dc.subjectFruit native
dc.subjectNutraceutical food
dc.subjectProtects effects
dc.titleBaru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage22
oaire.citation.issue8
oaire.citation.startPage1
oaire.citation.titleBiomolecules
oaire.citation.volume10
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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