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Effects of extraction solvent and samples origin in the antitumor and antimicrobial activity of Laurus nobilis L. leaves

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dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-19T15:26:19Z
dc.date.available2015-11-19T15:26:19Z
dc.date.issued2015
dc.description.abstractLaurus nobilis L., commonly known as laurel, belongs to Laureaceae family and it's a native plant from the Mediterranean region. It is mostly appreciated for its flavour as a culinary spice, being also consumed as infusion to treat some gastrointestinal problems [1]. It has been reported as a rich source of bioactive molecules, such as phenolic compounds and essential oils [2, 3]. Due to the exponential increase of oncological diseases and also the increased resistance to antibiotics, there is a growing concern in seeking new sources of antitumors and antimicrobials, being natural matrices such as plants promising sources. Herein, in vitro antitumor (against five different human tumor cell lines) and antimicrobial (antibacterial and antifungal) activities were evaluated on methanolic and aqueous extracts of wild and cultivated L. nobilis leaves. Furthermore, to understand how both bioactive extracts and the origin of laurel sample act differentially towards specific bacterial and fungal species and also selected human tumor cell lines, a statistics analysis was perfonned using two-dimensional prindpal component analysis (PCA). The origin (wild or cultivated) and extract type (methanolic or aqueous) of laurel samples act in a different manner for the same evaluated parameter, showing statistically significant differences in the origin, but not in the extract studied, or vice-versa. It was the extract type who showed most significant changes in the bioactivitjes studied in both laurel samples. From the PCA biplot, it became clear that wild samples were more effective to inhibit tumor cell lines growth. espedally HeLa, MCF7, NCI-H460 and HCT15. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except for Aspergillus niger, Aspergillus. fumigatus and Penicillium verrucosum. The differences in bioactivity might be related to the higher phenolic compounds content (flavonols, flavones and even, total phenolic compounds) found in the methanolic extracts. From the results obtained it is interesting to find out that considering the origin of laurel, wild or cultivated, it was possible to specify the bioactivity of the extract, methanolic our aqueous. Meaning, from the PCA biplot it is possible to choose the combination extract type/origin with potentially highest antitumor or antimicrobial effect, depending on the objective of the study.pt_PT
dc.identifier.citationDias, Maria Inês; Calhelha, Ricardo C.; Barreira, João C.M.; Queiroz, Maria João R.P.; Oliveira, M.B.P.P.; Soković, Marina; Ferreira, Isabel C.F.R. (2015). Effects of extraction solvent and samples origin in the antitumor and antimicrobial activity of Laurus nobilis L. leaves. In 2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12377
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleEffects of extraction solvent and samples origin in the antitumor and antimicrobial activity of Laurus nobilis L. leavespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Incentivo%2FEQB%2FLA0006%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.title2nd Symposium on Medicinal Chemistry of University of Minhopt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameDias
person.familyNameCalhelha
person.familyNameBarreira
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameJoão C.M.
person.givenNameIsabel C.F.R.
person.identifier144781
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person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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