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Yield, chemical composition and bioactivity of essential oils from common juniper (Juniperus communis L.) from different spanish origins

2023Journal article Open access
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dc.contributor.authorEsteban Pascual, Luis Saul
dc.contributor.authorMediavilla, Irene
dc.contributor.authorXavier, Virginie
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorLopez, Cesar
dc.contributor.authorBarros, Lillian
dc.date.accessioned2014-09-19T11:38:02Z
dc.date.available2014-09-19T11:38:02Z
dc.date.issued2023
dc.description.abstractEssential oils (EOs) obtained from Juniperus communis L. are frequently used in the production of bioproducts. However, there are no studies regarding industrial crops' production, allowing for better control of the quality and production of juniper EOs. To select the plant material for developing future crops of this species in northern Spain, four locations where this shrub species grows in the wild were selected and samples of both genera were collected. The EOs were obtained by steam distillation, and their chemical composition and bioactivity were evaluated. The results showed that the yield of EOs from male and female samples were within the usual reported ranges, varying between 0.24 and 0.58% (dry basis, d.b.). However, limonene content in three locations varied between 15 and 25%, which is between 100% and 200% higher than the values usually reported for other European countries. The antibacterial activity was determined by broth microdilution and showed that gram-positive bacteria were more susceptible to the tested EOs since, in general, lower MIC values were obtained compared to gram-negatives. The EOs from location 1 (L1F) and 2 (L2M) inhibited the growth of six out of the eight clinical strains tested. Samples from location 1 were particularly effective, exhibiting MBC against two gram-negative (E. coli and P. mirabilis) and one gram-positive bacteria (E. faecalis). Moreover, the majority of the EOs tested showed anti-inflammatory activity. Cytotoxic effect has been demonstrated in tumor cell lines, with the best results observed against gastric carcinoma (AGS) cells (GI(50) between 7 to 77 mu g/mL). Although generally presenting higher GI50, most samples also inhibited the growth of non-tumoral cells, particularly hepatocytes (PLP2 cells). Therefore, its use for their anti-proliferative activity should consider specific conditions to avoid damaging normal cells. Finally, the results and conclusions obtained led to the selection of the female shrubs from location 1 (L1F) as the plant material to be propagated in order to produce plants for a future juniper crop.por
dc.description.sponsorshipThis research received funding from the Bio Based Industries Joint Undertaking (JU), under grant agreement No 887917 BeonNAT. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Bio Based Industries Consortium, and the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). L. Barros and R.C. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for their contracts.
dc.identifier.citationEsteban, Luis Saúl; Mediavilla, Irene; Xavier, Virginie; Amaral, Joana S.; Pires, Tânia C.S.P.; Calhelha, Ricardo C.; Lopez, Cesar; Barros, Lillian (2023). Yield, chemical composition and bioactivity of essential oils from common juniper (Juniperus communis L.) from different spanish origins. Molecules. eISSN 1420-3049. 28:11, p. 1-15por
dc.identifier.doi10.3390/molecules28114448
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/10484
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPI
dc.subjectDistillationpor
dc.subjectFoliagepor
dc.subjectEssential oilpor
dc.subjectAntioxidant activitypor
dc.subjectCytotoxicity
dc.subjectAnti-inflammatory activity
dc.titleYield, chemical composition and bioactivity of essential oils from common juniper (Juniperus communis L.) from different spanish originspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespor
person.familyNameXavier
person.familyNameAmaral
person.familyNamePires
person.familyNameCalhelha
person.familyNameBarros
person.givenNameVirginie
person.givenNameJoana S.
person.givenNameTânia C.S.P.
person.givenNameRicardo C.
person.givenNameLillian
person.identifier2118829
person.identifier469085
person.identifier.ciencia-idB212-37BC-7FB4
person.identifier.ciencia-id5319-7DE8-BEDA
person.identifier.ciencia-id321E-2D96-00CA
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0001-7508-1245
person.identifier.orcid0000-0002-3648-7303
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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