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Evaluation of antitumoral and antioxidant activities of the hydroalcoholic extract and fractions obtained from the fruit pericarp of Sapindus saponaria L.

2023Journal article Open access
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dc.contributor.authorSantos Filho, José Rivaldo dos
dc.contributor.authorSantos, Everton da Silva
dc.contributor.authorMandim, Filipa
dc.contributor.authorMolina, Adriana K.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonçalves, Regina Aparecida Correia
dc.contributor.authorOliveira, Arildo José Braz de
dc.contributor.authorFerreira, Izabel Cristina Piloto
dc.date.accessioned2023-02-23T15:24:02Z
dc.date.available2023-02-23T15:24:02Z
dc.date.issued2023
dc.description.abstractThe fruits of Sapindus saponaria L., popularly known as 'saboeiro', have been used in medicine. This study evaluated the antioxidant and antitumor activities of the hydroethanolic extract (HAE) and fractions obtained from the fruit pericarp of S. saponaria. The HAE was obtained from the S. saponaria fruit pericarp by maceration; this was followed by fractionation using reversed-phase solid-phase extraction, resulting in fractions enriched with acyclic sesquiterpenic oligoglycosides (ASOG) and saponins (SAP1, and SAP2), confirmed by mass spectrometry with electrospray ionization (ESI-QTOF-MS). The greatest citotoxic activity was observed with the SAP1 fraction against the CaCo2 cell line with a GI(50) of 8.1 mu g mL(-1), while the SAP2 fraction had a GI(50) of 13.6 mu g mL(-1) against CaCo2. The HAE demonstrated the greatest antioxidant activity. S. saponaria has potential therapeutic use in the pharmaceutical industry as a natural anti-oxidant or antitumor product.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos Filho, José Rivaldo dos; Santos, Everton da Silva; Mandim, Filipa; Molina, Adriana K.; Barros, Lillian; Gonçalves, Regina Aparecida Correia; Oliveira, Arildo José Braz de; Ferreira, Izabel Cristina Piloto (2023). Evaluation of antitumoral and antioxidant activities of the hydroalcoholic extract and fractions obtained from the fruit pericarp of Sapindus saponaria L. Natural Product Research. EISSN 1478-6427. 38:), p. 1002–1006pt_PT
dc.identifier.doi10.1080/14786419.2023.2211214pt_PT
dc.identifier.eissn1478-6427
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/10198/27147
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAcyclic sesquiterpenic oligoglycosidespt_PT
dc.subjectBiological activitypt_PT
dc.subjectSaponinspt_PT
dc.subjectSapindus saponariapt_PT
dc.titleEvaluation of antitumoral and antioxidant activities of the hydroalcoholic extract and fractions obtained from the fruit pericarp of Sapindus saponaria L.pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleNatural Product Researchpt_PT
person.familyNameMandim
person.familyNameMolina
person.familyNameBarros
person.givenNameFilipa
person.givenNameAdriana K.
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-idC110-0167-E58D
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6234-2212
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbcc274d4-7e6c-46a8-8e49-2752f9dbfbcd
relation.isAuthorOfPublicationdc9b5b67-c45e-4fbe-8af1-8cec9adb5cd9
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscoverybcc274d4-7e6c-46a8-8e49-2752f9dbfbcd

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