Logo do repositório
 
Publicação

Enhancing artemisinin solubility in aqueous solutions: searching for hydrotropes based on ionic liquids

2021Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorSales, Isabela
dc.contributor.authorAbranches, Dinis O.
dc.contributor.authorCosta, Pedro
dc.contributor.authorSintra, Tânia E.
dc.contributor.authorVentura, Sónia P.M.
dc.contributor.authorMattedi, Silvana
dc.contributor.authorCoutinho, João A.P.
dc.contributor.authorFreire, Mara G.
dc.contributor.authorPinho, Simão
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:39Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:39Z
dc.date.issued2021
dc.description.abstractArtemisinin is a sesquiterpenoid lactone peroxide, known for its potent antimalarial activity that can be extracted from Artemisia annua L. This compound is only sparingly soluble in water, making its extraction using environmental-friendly and non-toxic aqueous solvents difficult. In the attempt to overcome this limitation, hydrotropes, which are a class of compounds that can assist in increasing the solubility of hydrophobic solutes in water, were investigated in this work. In particular, the hydrotropic capability of ionic liquids (ILs) on the aqueous solubility of artemisinin was studied. The effects of IL concentration and anion nature of 1-butyl-3-methylimidazolium-based ILs on the solubility of artemisinin at 303.2 K in water were evaluated. It is here shown the excellent capacity of ILs containing thiocyanate or dicyanamide anions to enhance the solubility of artemisinin in aqueous media, with a magnitude comparable to that obtained with the best organic solvents. Furthermore, solvatochromic parameters of the ILs aqueous solutions were also measured and combined with COSMO-RS and the cooperative hydrotropy model to establish relations between the artemisinin solubility enhancement and the solvent characteristics. The solubility enhancement of artemisinin is favored by the apolarity of the medium and the lower hydrogen-bond acceptor character of the hydrotrope.en_EN
dc.description.sponsorshipThis work was developed within the scope of the projects CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, CIMO-Mountain Research Center, UIDB/00690/2020, all financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. Isabela Sales and Silvana Mattedi thanks the finantial support from CAPES and CNPq/Brazil (CAPES: Proc. 88881.189075/2018-01 and 88887.494428/2020-00. CNPq: Grant 303089/2019-9 and Proc.438036/2018-2).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSales, Isabela; Abranches, Dinis O.; Costa, Pedro; Sintra, Tânia E.; Ventura, Sónia P.M.; Mattedi, Silvana; Coutinho, João A.P.; Freire, Mara G.; Pinho, Simão P. (2021). Enhancing Artemisinin Solubility in Aqueous Solutions: Searching for Hydrotropes based on Ionic Liquids. Fluid Phase Equilibria. ISSN 0378-3812. 534, p. 1-9en_EN
dc.identifier.doi10.1016/j.fluid.2021.112961en_EN
dc.identifier.issn0378-3812
dc.identifier.urihttp://hdl.handle.net/10198/24364
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.subjectaqueous solubilityen_EN
dc.subjectArtemisininen_EN
dc.subjectHydrotropyen_EN
dc.subjectIonic liquidsen_EN
dc.subjectSolvatochromic parametersen_EN
dc.titleEnhancing artemisinin solubility in aqueous solutions: searching for hydrotropes based on ionic liquidsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePinho
person.givenNameSimão
person.identifier810882
person.identifier.ciencia-id481D-73AD-8D0F
person.identifier.orcid0000-0002-9211-857X
person.identifier.ridD-4148-2013
person.identifier.scopus-author-id7003570175
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication8ef7789a-34f3-4915-a666-4efe26272a30
relation.isAuthorOfPublication.latestForDiscovery8ef7789a-34f3-4915-a666-4efe26272a30
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication.latestForDiscovery29718e93-4989-42bb-bcbc-4daff3870b25

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
81.pdf
Tamanho:
1.52 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.75 KB
Formato:
Plain Text
Descrição:
Ver/Abrir

Coleções

CIMO - Artigos em Revistas Indexados à WoS/Scopus