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In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides

2017Journal article Open access
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dc.contributor.authorMartins, Vitor Manuel Ramalheira
dc.contributor.authorSimões, Joana A.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorCruz, Maria T.
dc.contributor.authorDomingues, Maria R.M.
dc.contributor.authorCoimbra, Manuel A.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:36Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:36Z
dc.date.issued2017
dc.description.abstractPterospartum tridentatum (L.) Willk. decoctions of dried inflorescences are used in Portugal due to their claimed beneficial properties for various health disorders. To disclose the potential contribution of its polysaccharides to health benefits, in this work, hot water extracts from P. tridentatum inflorescences were prepared and fractionated by ethanol precipitation and anion exchange chromatography. The fraction rich in acetylated galactomannans evidenced an increase in nitric oxide (NO) production by macrophages. This activity decreased 60–75% after saponification, confirming that acetylation is an important structural feature for this biological property. In addition, the treatment of pectic polysaccharides with endo-polygalacturonase showed that type-I and type-II arabinogalactans, as well as low molecular weight galacturonans and xyloglucans, may also contribute to macrophage NO production. Thus, the polysaccharides present in P. tridentatum dried inflorescences may contribute to the health beneficial properties frequently attributed to the decoctions of this plant.pt_PT
dc.description.sponsorshipThanks are due to Fundac¸ ão para a Ciência e a Tecnologia(FCT, Portugal), European Union, QREN, FEDER, and COMPETEfor funding the QOPNA (Project PEst-C/QUI/UI0062/2013; FCOMP-01-0124-FEDER-037296), CNC (Project UID/NEU/04539/2013), andCIMO Research Units, and RNEM (REDE/1504/REM/2005 thatconcerns the Portuguese Mass Spectrometry Network). Thanksare also due to FCT for the PhD Grant of Vitor Martins(SFRH/PROTEC/49249/2008) and to Dr. Ana Maria Carvalho, fromCIMO, for the identification of the plant material.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMartins, Vitor M.R.; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, M. Rosário; Coimbra, Manuel A. (2017). In vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharides. Carbohydrate Polymers. ISSN 0144-8617. 157, p. 176-184en_EN
dc.identifier.doi10.1016/j.carbpol.2016.09.079pt_PT
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10198/15308
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.relationSFRH/PROTEC/49249/2008
dc.subjectAcetylated galactomannanen_EN
dc.subjectMass spectrometryen_EN
dc.subjectNitric oxideen_EN
dc.subjectP. tridentatumen_EN
dc.subjectPectic polysaccharidesen_EN
dc.titleIn vitro macrophage nitric oxide production by Pterospartum tridentatum (L.) Willk. inflorescence polysaccharidesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FQUI%2FUI0062%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FNEU%2F04539%2F2013/PT
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameMartins
person.familyNameFerreira
person.givenNameVitor Manuel Ramalheira
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id7C1B-3C44-BDC5
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-4144-898X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id57191364121
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
relation.isAuthorOfPublicationba9148ec-024a-478f-8498-fb3b59950cc7
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoveryba9148ec-024a-478f-8498-fb3b59950cc7
relation.isProjectOfPublicationc6cfbfe6-0981-49d7-8a9b-41f9904a0330
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relation.isProjectOfPublication.latestForDiscoveryc6cfbfe6-0981-49d7-8a9b-41f9904a0330

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