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Propolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, and In Vitro Bioactivity Studies

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPinto, Maria Beatriz
dc.contributor.authorPires, Patrícia C.
dc.contributor.authorCorreia, Mafalda
dc.contributor.authorMoço, Gabriela
dc.contributor.authorSousa-Oliveira, Inês
dc.contributor.authorSousa, Maria João
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorFalcão, Soraia
dc.contributor.authorMazzola, Priscila Gava
dc.contributor.authorVeiga, Francisco
dc.contributor.authorPaiva-Santos, Ana Cláudia
dc.date.accessioned2026-01-23T16:46:02Z
dc.date.available2026-01-23T16:46:02Z
dc.date.issued2025
dc.description.abstractPropolis, produced by Apis melliferabees, is composed of several biologically relevant phenolic compounds with known analgesic, anti-inflammatory, antitumor, antioxidant, immunomodulatory, wound healing, and antibacterial effects, having gained significant interest for therapeutic and cosmetic purposes. Niosomes, self-assembled vesicular nanosystems, are highly researched for topical delivery due to providing controlled and sustained release, protecting encapsulated compounds from degradation, improving stability, and having good biocompatibility and biodegradability. This work aimed to develop novel propolis-loaded niosomes with small and homogeneous particle size, high encapsulation efficiency, controlled release, adequate stability, relevant bioactivity, and high safety for topical application, for therapeutic and/or cosmetic purposes. Aided by quality by design (QbD) analysis, niosomes containing Tween 20, Kolliphor RH 40, cetyl alcohol, and/or cholesterol were produced by thin-film hydration followed by extrusion, with small particle size (between 100 and 200 nm), homogeneous distribution (PDI below 0.2), relevant zeta-potential (around -38 mV), good stability both under refrigeration and at room temperature, high encapsulation efficiency (ranging from 78.8 to 87.4%), and a controlled release profile, relevant to ensure prolonged bioactivity at the application site. Adequate concentration-dependent in vitro safety in keratinocytes and fibroblasts (up to 12.5 or 25 mu g/mL) was demonstrated as well, with some niosomal formulations also showing a low irritative potential in a HET-CAM test, and relevant in vitro anti-inflammatory potential (IC50 from 14.90 to 17.89 ng/mL). These novel nanoplatforms, containing a nature-derived hydrophobic compound with various relevant bioactivities, could serve as versatile and advantageous formulations in both pharmaceutical and cosmetic contexts of application.eng
dc.description.sponsorshipThis study was supported by Research and Development Project grant 2022.05270.PTDC,supported by Fundação para a Ciência e a Tecnologia I.P. (FCT, Portugal).
dc.identifier.citationPinto, MB; Pires, PC; Correia, M; Moço, G; Sousa-Oliveira, I; Sousa, Maria João; Calhelha, Ricardo C.; Vilas-Boas, Miguel; Falcão, Soraia; Mazzola, PG; Veiga, F; Paiva-Santos, AC (2025). Propolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, and In Vitro Bioactivity Studies. ACS Pharmacology & Translational Science. ISSN 2575-910. 8:7, p. 2220–2246
dc.identifier.doi10.1021/acsptsci.5c00253
dc.identifier.issn2575-9108
dc.identifier.issn2575-9108
dc.identifier.urihttp://hdl.handle.net/10198/35595
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Chemical Society
dc.relation.ispartofACS Pharmacology & Translational Science
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectAnti-inflammatory
dc.subjectControlled release
dc.subjectNiosomes
dc.subjectPropolis
dc.subjectQbD
dc.subjectTopical delivery
dc.titlePropolis-Loaded Niosomes for Dermopharmaceutic and Cosmetic Applications: Development, Stability, Safety, and In Vitro Bioactivity Studieseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2246
oaire.citation.issue7
oaire.citation.startPage2220
oaire.citation.titleACS Pharmacology & Translational Science
oaire.citation.volume8
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSousa
person.familyNameCalhelha
person.familyNameVilas-Boas
person.familyNameFalcão
person.givenNameMaria João
person.givenNameRicardo C.
person.givenNameMiguel
person.givenNameSoraia
person.identifier1693134
person.identifier711432
person.identifier.ciencia-idD91E-3571-3979
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idA918-C6FF-81A4
person.identifier.ciencia-idD41A-6BED-4CBB
person.identifier.orcid0000-0002-9946-4926
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-8665-5280
person.identifier.orcid0000-0003-3735-6951
person.identifier.ridJ-2172-2014
person.identifier.ridI-5949-2013
person.identifier.scopus-author-id55230282700
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id6602648497
person.identifier.scopus-author-id14832459200
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relation.isAuthorOfPublication5746ab3e-8ffe-4e26-9a41-8392cf031f28
relation.isAuthorOfPublication.latestForDiscoveryda5c7615-9844-4fdf-b4d4-64d0c8e72de0

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