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Seasonal variation in bioactive properties and phenolic composition of cardoon (Cynara cardunculus var. altilis) bracts

2021Journal article Open access
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dc.contributor.authorMandim, Filipa
dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorKostić, Marina
dc.contributor.authorSoković, Marina
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T14:21:30Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T14:21:30Z
dc.date.issued2021
dc.description.abstractCardoon (Cynara cardunculus L.) bracts were collected at different maturation stages to investigate seasonal changes in the phenolic compounds profile and in vitro bioactivities. Among the 12 phenolic compounds tentatively identified, 3,5-O-dicaffeoylquinic acid (21.83 mg/g extract) and apigenin-7-O-glucuronide (10.6 mg/g extract) were the most abundant. Immature bracts (C1: principal growth stage (PGS) 5) had the highest phenolic compounds content, and anti-inflammatory (IC50 = 72 µg/mL) and cytotoxic (GI50 of 30–79 µg/mL) activities. Moreover, extract C1 inhibited efficiently the formation of thiobarbituric acid reactive substances (TBARS; IC50 = 26.8 µg/mL), while extract C8 (PGS 8/9) was more effective against oxidative haemolysis (IC50 38 and 75 µg/mL). The highest antibacterial and antifungal activities were attributed to samples C1 and C6 (PGS 7/8) and samples C2 (PGS 5/6) and C4 (PGS 6/7), respectively. Overall, the obtained results suggest the seasonal changes of polyphenolic composition and bioactivity of cardoon bracts of variable maturity.en_EN
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES to CIMO (UIDB/00690/2020). National funding by FCT, through the institutional scientific employment program-contract with M.I. Dias, J. Pinela, and L. Barros. To FCT for the PhD grant (SFRH/BD/146614/2019) of F. Mandim. The authors are also grateful to FEDERInterreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E; to the project TRANSCoLAB (0612_TRANS_CO_LAB_2_P), and to the Ministry of Education, Science and Technological Development of the Republic of Serbia (451-03-68/2020-14/200007).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMandim, Filipa; Petropoulos, Spyridon A.; Dias, Maria Inês; Pinela, José; Kostić, Marina; Soković, Marina; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Seasonal variation in bioactive properties and phenolic composition of cardoon (Cynara cardunculus var. altilis) bracts. Food Chemistry. ISSN 0308-8146. 336, p. 1-8en_EN
dc.identifier.doi10.1016/j.foodchem.2020.127744en_EN
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/24250
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Center
dc.relationIntegrated strategies for the development of a novel functional beverage with sustainable production systems
dc.subjectAntimicrobial activityen_EN
dc.subjectAntioxidant/anti-inflammatoryen_EN
dc.subjectCaffeoylquinic aciden_EN
dc.subjectCynara cardunculusen_EN
dc.subjectCytotoxic activityen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectSeasonal changesen_EN
dc.titleSeasonal variation in bioactive properties and phenolic composition of cardoon (Cynara cardunculus var. altilis) bractsen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleIntegrated strategies for the development of a novel functional beverage with sustainable production systems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMandim
person.familyNameDias
person.familyNamePinela
person.familyNameFerreira
person.familyNameBarros
person.givenNameFilipa
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
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person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id771C-2B43-B108
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0001-7523-1637
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridM-8242-2013
person.identifier.ridB-4466-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id54392272800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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