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Cellular antioxidant, anti-inflammatory, and antiproliferative activities from the flowers, leaves and fruits of Gallesia integrifolia spreng harms

2023Journal article Open access
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dc.contributor.authorSilva, Gabriela Catuzo Canonico
dc.contributor.authorMachado, Mariane de Almeida
dc.contributor.authorSakumoto, Karina
dc.contributor.authorInumaro, Rodrigo Sadao
dc.contributor.authorGonçalves, José Eduardo
dc.contributor.authorMandim, Filipa
dc.contributor.authorVaz, Josiana A.
dc.contributor.authorValle, Juliana Silveira do
dc.contributor.authorFaria, Maria Graciela Iecher
dc.contributor.authorRuiz, Suelen Pereira
dc.contributor.authorPiau Junior, Ranulfo
dc.contributor.authorGonçalves, Daniela Dib
dc.contributor.authorGazim, Zilda Cristiani
dc.date.accessioned2012-03-09T10:26:20Z
dc.date.available2012-03-09T10:26:20Z
dc.date.issued2023
dc.description.abstractGallesia integrifolia, a notable species in the Atlantic Forest, has been traditionally employed in folk medicine for treating rheumatism, asthma, and worms. This study investigated the cellular antioxidant, antiproliferative, and anti-inflammatory activities of the essential oils (EOs) and crude extracts (CEs) from G. integrifolia flowers, fruits, and leaves. The chemical identification of EOs was performed by GC-MS and CEs by UHPLC-MS. Cellular antioxidant and anti-inflammatory activities were assessed through mouse macrophage cell culture. In addition, the antiproliferative potential was evaluated in gastric, colorectal, breast, and lung tumor cell lines and non-tumor VERO cells. EOs predominantly contained organosulfur compounds in flowers (96.29%), fruits (94.94%), and leaves (90.72%). We found the main compound is 2,2 & PRIME;-Disulfanediyldiethanethiol in the EOs of flowers (47.00%), leaves (41.82%), and fruits (44.39%). Phenolic compounds were identified in CEs. The EOs and CEs demonstrated potential against the tumor cell lines tested (GI(50) between 51 and 230 & mu;g/mL). The selectivity index values were greater than 1.0 (1.01 to 3.37), suggesting a relative safety profile. Moreover, the anti-inflammatory activity IC50 ranged from 36.00 to 268 & mu;g/mL, and the cellular oxidation inhibition ranged from 69% to 82%. The results suggest that oils and extracts derived from G. integrifolia have potential for use in various industrial sectors.por
dc.description.sponsorshipThis research was funded by Universidade Paranaense, UniCesumar, Foundation for Science and Technology (FCT, Portugal) financial support to CIMO (UIDB/00690/2020 and UIDP/00690/ 2020) and SusTEC (LA/P/0007/2021), Ph.D. grant of F.M. (SFRH/BD/146614/2019), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (finance code 001), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (J.S.d.V.; D.D.G. and Z.C.G. fellowships), and Fundação Araucária.
dc.identifier.citationSilva, Gabriela Catuzo Canonico; Machado, Mariane de Almeida; Sakumoto, Karina; Inumaro, Rodrigo Sadao; Gonçalves, José Eduardo; Mandim, Filipa; Vaz, Josiana A.; Valle, Juliana Silveira do; Faria, Maria Graciela Iecher; Ruiz, Suelen Pereira; Piau Junior, Ranulfo; Gonçalves, Daniela Dib; Gazim, Zilda Cristiani (2023). Cellular antioxidant, anti-inflammatory, and antiproliferative activities from the flowers, leaves and fruits of Gallesia integrifolia spreng harms. Molecules. eISSN 1420-3049. 28:14, p. 1-24por
dc.identifier.doi10.3390/molecules28145406
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/6684
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.titleCellular antioxidant, anti-inflammatory, and antiproliferative activities from the flowers, leaves and fruits of Gallesia integrifolia spreng harmspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespor
person.familyNameMandim
person.familyNameVaz
person.givenNameFilipa
person.givenNameJosiana A.
person.identifier.ciencia-idF318-9049-EB99
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.orcid0000-0002-6494-2326
person.identifier.orcid0000-0002-6989-1169
person.identifier.scopus-author-id16305323200
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationbcc274d4-7e6c-46a8-8e49-2752f9dbfbcd
relation.isAuthorOfPublication1c1a2cb9-5a36-47ba-bca0-ffcbef28df18
relation.isAuthorOfPublication.latestForDiscoverybcc274d4-7e6c-46a8-8e49-2752f9dbfbcd

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