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Authors
Advisor(s)
Abstract(s)
This research is devoted to the design and synthesis of
amphiphilic/stimuli-responsive block copolymers for encapsulation of
polyphenols in polymersomes. The Reversible Addition-
Fragmentation Chain Transfer (RAFT) polymerization technique is
used to get tailored amphiphilic block copolymers. Multiple
combinations between hydrophilic/hydrophobic monomers, RAFT
agents and initial compositions are the main design variables of the
synthesis runs. Experimental studies are guided by modeling tools to
aid in the design of the materials (e.g. to specify the sizes of the two
blocks, pH sensitivity). Isolated polyphenols (e.g. resveratrol,
quercetin) and more complex extracts from different kinds of plants
are afterwards encapsulated in polymersomes, aiming at the
development of carriers for protection and controlled release of these
bioactive compounds. It is shown that the produced aggregates have a
long colloidal stability and are promising vehicles for the stimulatedrelease
of polyphenols.
Description
Keywords
RAFT polymerization Block Copolymers Amphiphilic block copolymers Stimuli-responsive block copolymers Polymersomes Polyphenols