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Association between handgrip strength and mortality in individuals undergoing hemodialysis: A retrospective cohort study

2025Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorKlippel, Leticia de Paiva Souza
dc.contributor.authorMartins, Cleodice Alves
dc.contributor.authorBarbosa, Karen dos Santos
dc.contributor.authorLeandro, Larissa Vitória Batista
dc.contributor.authorCattafesta, Monica
dc.contributor.authorCunha, Alexandre Cardoso da
dc.contributor.authorSoares, Ana Cristina de Oliveira
dc.contributor.authorPrado, Camila Bruneli do
dc.contributor.authorFerreira, Júlia Rabelo Santos
dc.contributor.authorPeterle, Fernanda Zobole
dc.contributor.authorAlmeida-de-Souza, Juliana
dc.contributor.authorHaraguchi, Fabiano Kenji
dc.contributor.authorFurtado, Elane Viana Hortegal
dc.contributor.authorNeto, Edson Theodoro dos Santos
dc.contributor.authorSalaroli, Luciane Bresciani
dc.date.accessioned2025-11-04T16:24:32Z
dc.date.available2025-11-04T16:24:32Z
dc.date.issued2025
dc.description.abstractHandgrip strength offers a valuable method to detect changes and reduced muscle strength and frailty and can help improve prognosis by early diagnosis. Therefore, the aim of the study was to evaluate the association between reduced muscle strength and mortality in individuals undergoing hemodialysis. Retrospective cohort study with 994 individuals. Sociodemographic, clinical, and lifestyle variables were obtained from a 2019 study. Mortality data were sourced from death certificates recorded from 2019 to 2022 in the Mortality Information System. Muscle strength was classified based on the following cut-off values: <27 kg for men and <16 kg for women. Survival curves were constructed using the Kaplan-Meier method and Cox Regression was used to evaluate the effect of handgrip strength and age on the time. More than 65 % of individuals in the sample show depleted strength, most of which were older adults (43.25 %, p < 0.001) and men (41.32 %, p = 0.008). Older adults with depleted strength showed a significantly higher number of observed deaths than expected ones (p < 0.001). After adjustment, HGS remained a significant predictor, associated with a 49 % increased risk of death (95 % CI: 1.16-1.91, p = 0.002). Having more than 11 years of formal education demonstrated a protective effect, reducing the risk of death by 1.6 times (95 % CI: 0.41-0.88, p = 0.009). Diabetes was found to be associated with almost a twofold increase in the risk of mortality (95 % CI: 1.54-2.49, p < 0.001). The decrease in handgrip strength predicts mortality in individuals undergoing hemodialysis with the risk being higher among older adults, those with diabetes and individuals with fewer than 11 years of education. (c) 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.eng
dc.description.sponsorshipThis study received funding from the Espírito Santo Research and Innovation Support Foundation under EDITAL N° 28/2022 - UNIVERSAL.
dc.identifier.citationKlippel, Leticia de Paiva Souza; Martins, Cleodice Alves; Barbosa, Karen dos Santos; Vito, Larissa; Cattafesta, Monica; Cunha, Alexandre Cardoso da; Soares, Ana Cristina de Oliveira; Prado, Camila Bruneli do; Ferreira, Julia Rabelo Santos; Peterle, Fernanda Zobole; Almeida-de-Souza, Juliana; Haraguchi, Fabiano Kenji; Furtado, Elane Viana Hortegal; Neto, Edson Theodoro dos Santos; Theodoro, Edson (2025). Association between handgrip strength and mortality in individuals undergoing hemodialysis: A retrospective cohort study. Clinical Nutrition ESPEN. ISSN 2405-4577. 70 p. 249-255
dc.identifier.doi10.1016/j.clnesp.2025.09.034
dc.identifier.issn2405-4577
dc.identifier.urihttp://hdl.handle.net/10198/34943
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.ispartofClinical Nutrition ESPEN
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectChronic kidney disease
dc.subjectMuscle strength
dc.subjectHemodialysis
dc.subjectMortality
dc.titleAssociation between handgrip strength and mortality in individuals undergoing hemodialysis: A retrospective cohort studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage255
oaire.citation.startPage249
oaire.citation.titleClinical Nutrition ESPEN
oaire.citation.volume70
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlmeida-de-Souza
person.givenNameJuliana
person.identifier.ciencia-idFA14-073E-C116
person.identifier.orcid0000-0002-2578-3684
person.identifier.scopus-author-id57194551953
relation.isAuthorOfPublication9d064d3f-d90d-41e9-b993-297a4e808396
relation.isAuthorOfPublication.latestForDiscovery9d064d3f-d90d-41e9-b993-297a4e808396

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