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Electrospun Fibrous Architectures for Localized Delivery of Photosensitizers in Cancer Therapy

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorGomes, Cátia V.
dc.contributor.authorCosta, Sofia M.
dc.contributor.authorOliveira, João S.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorLourenço, Leandro M. O.
dc.contributor.authorFangueiro, Raul
dc.contributor.authorFerreira, Diana P.
dc.date.accessioned2026-03-20T14:33:50Z
dc.date.available2026-03-20T14:33:50Z
dc.date.issued2026
dc.description.abstractPhotodynamic therapy (PDT) is a promising localized strategy for the treatment of cervical cancer, ranking as the fourth most common cancer among women worldwide. The integration of photosensitizers (PSs) in localized drug delivery systems (DDSs), particularly in electrospun nanofibers, holds tremendous potential to overcome the drawbacks of their systemic administration. Exploring multilayer fibrous architectures provides a versatile therapeutic platform to design the next generation of localized DDS. In this work, localized implants for cancer treatment using PDT were developed using polyhydroxyalkanoate (PHA), chitosan (CS) and polyethylene oxide (PEO) as biopolymers and a porphyrin (Por) as PS, following two approaches: blended PHA/Por electrospun microfibers and multilayered membranes (PHA–Por/CS/PEO) produced by sequential electrospinning. The synthesized Por displayed higher cytotoxicity in light compared to dark against tumor cells. All the developed membranes were characterized regarding their morphology, wettability, absorption and fluorescence properties. PHA–Por membranes exhibited overall uniform fibrous morphologies with successful Por incorporation. Nonetheless, they presented a highly hydrophobic surface, compromising the Por release and cell–material interactions. In contrast, multilayer PHA–Por/CS/PEO membranes demonstrated enhanced hydrophilicity and enabled sustained Por release. Upon light irradiation, these membranes induced a significantly greater inhibition of HeLa cell proliferation (29.61%) compared to dark conditions (6.21%), confirming their photodynamic activity.eng
dc.description.sponsorshipThis research was funded by national funds through FCT—Fundação para a Ciência e a Tecnologia, I.P. and Programa de Recuperação e Resiliência (PRR) through NextGenerationEU from the European Union, under the Strategic Projects UID/00264/2025 and UID/PRR/00264/2025 of the 2C2T—Centro de Ciência e Tecnologia Têxtil (https://doi.org/10.54499/UID/00264/2025 and https://doi.org/10.54499/UID/PRR/00264/2025), and under the project DRI/India/0447/2020 (https://doi.org/10.54499/DRI/India/0447/2020); National funding by FCT. P.I. through the scientific employment program contract for the contract of R. Calhelha (CEEC Institutional DOI:10.54499/CEECINST/00016/2018/CP1505/CT0009) and for the financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). LAQV-REQUIMTE (LA/P/0008/2020, DOI: 10.54499/LA/P/0008/2020; UIDP/50006/2020, DOI: 10.54499/UIDP/50006/2020; and UIDB/50006/2020, DOI: 10.54499/UIDB/50006/2020), and COMPETE2030-FEDER-00799000.
dc.identifier.citationGomes, Catia V.; Costa, Sofia M.; Oliveira Joao S.; Calhelha, Ricardo C.; Lourenço, Leandro M. O.; Fangueiro, Raul; Ferreira, Diana P. (2026). Electrospun Fibrous Architectures for Localized Delivery of Photosensitizers in Cancer Therapy. Molecules. ISSN 1420-3049. 31:5, p. 1-20
dc.identifier.doi10.3390/molecules31050842
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/36172
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for Textile Science and Technology
dc.relationPersonal Protective equipment for active filtration of microorganisms based on electrospun nanofiber membranes<br><br>
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.ispartofMolecules
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCancer
dc.subjectPhotodynamic therapy
dc.subjectLocalized drug delivery
dc.subjectSystems
dc.subjectBiopolymers
dc.subjectElectrospinning
dc.subjectMultilayer fibrous structures
dc.titleElectrospun Fibrous Architectures for Localized Delivery of Photosensitizers in Cancer Therapyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/CTM/00264/2019
oaire.awardNumberDRI/India/0447/2020
oaire.awardNumberUIDP/00690/2020
oaire.awardNumberLA/P/0007/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardTitleCentre for Textile Science and Technology
oaire.awardTitlePersonal Protective equipment for active filtration of microorganisms based on electrospun nanofiber membranes<br><br>
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FCTM%2F00264%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/DRI%2FIndia%2F0447%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.citation.endPage20
oaire.citation.issue5
oaire.citation.startPage1
oaire.citation.titleMolecules
oaire.citation.volume31
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCalhelha
person.givenNameRicardo C.
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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