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Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)

2021Journal article Open access
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dc.contributor.authorSharkawy, Asma
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorRodrigues, Alírio
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T10:27:16Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T10:27:16Z
dc.date.issued2021
dc.description.abstractPickering emulsions (PEs) are attracting increasing attention in the areas of food, cosmetic and pharmaceutical applications owing to their surfactant-free and eco-friendly nature. Herein, PEs stabilized by chitosan/collagen peptides (CH/CP) nanoparticles were assessed as green surfactant-free vehicles for the topical delivery of cannabidiol (CBD), a highly lipophilic unstable drug that is finding an increasing appeal in the cosmetic market. The influence of the oil phase volume fraction (φ) and the oil type on the emulsion properties, stability, rheological properties, as well as on the ex-vivo skin absorption of CBD was evaluated. The PE prepared with olive oil (φ = 0.6) exhibited elastic gel-like properties and demonstrated long-term stability after 5 months of storage, with a CBD content of 99.45% of the initially added amount. The skin absorption studies showed that CBD was retained in high amounts in the stratum corneum, while the CBD skin permeation was extremely low, indicating that the produced formulations are suitable as topical delivery vehicles. ATR-FTIR examination of the treated skin samples confirmed that the produced PEs were able to overcome the stratum corneum barrier. These findings suggest that the PEs stabilized with CH/CP nanoparticles provide an effective surfactant-free alternative for the topical delivery of CBD.en_EN
dc.description.sponsorshipThis work was financially supported by the Base Funding – UIDB/50020/2020 of the Associate Laboratory LSRE-LCM – funded by national funds through FCT/MCTES (PIDDAC) and the Base Funding – UIDB/00690/2020 of CIMO – Centro de Investigaç˜ao de Montanha – funded by national funds through FCT/MCTES (PIDDAC). The work was also supported by UIDB/50006/2020 and UIDP/50006/2020 by the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through national funds. The authors acknowledge the technical support of the i3S, University of Porto. Asma Sharkawy gratefully acknowledges the Foundation for Science and Technology (FCT, Portugal) for the doctoral scholarship (PD/BD/135085/2017), and Dr. Carina Costa (at the LSRE) for the invaluable help. Ana Margarida Silva (SFRH/BD/144994/2019) is thankful for the Ph.D. grant from the Portuguese Foundation for Science and Technology. Francisca Rodrigues is thankful for her contract (CEECIND/01886/2020) financed by FCT/MCTES—CEEC Individual 2020 Program Contract. The graphical abstract was created using BioRender. com, with a publication license.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSharkawy, Asma; Silva, Ana Margarida; Rodrigues, Francisca; Barreiro, Filomena; Rodrigues, Alírio (2021). Pickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD). Colloids and Surfaces A: Physicochemical and Engineering Aspects. ISSN 0927-7757. 631, p. 1-14en_EN
dc.identifier.doi10.1016/j.colsurfa.2021.127677en_EN
dc.identifier.issn0927-7757
dc.identifier.urihttp://hdl.handle.net/10198/24225
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationCEECIND/01886/2020
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationMountain Research Center
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
dc.relationFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
dc.subjectCBDen_EN
dc.subjectChitosanen_EN
dc.subjectEmulsion stabilityen_EN
dc.subjectPickering emulsionsen_EN
dc.subjectSkin absorptionen_EN
dc.subjectTopical drug deliveryen_EN
dc.titlePickering emulsions stabilized with chitosan/collagen peptides nanoparticles as green topical delivery vehicles for cannabidiol (CBD)en_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleDevelopment and characterization of encapsulation systems for the protection and controlled release of active agents
oaire.awardTitleFrom soil to skin: Eco-friendly extract from kiwiberry leaves for prevention of skin aging process
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F135085%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F144994%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameBarreiro
person.givenNameFilomena
person.identifier.ciencia-id3418-47D5-5746
person.identifier.orcid0000-0002-6844-333X
person.identifier.ridL-9802-2014
person.identifier.scopus-author-id57188719717
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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