Repository logo
 
Publication

Antimicrobial activity, growth inhibition of human tumor cell lines and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts.

2013Journal article Open access
Simple item page
dc.contributor.authorRashed, Khaled N.
dc.contributor.authorĆirić, Ana
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSoković, Marina
dc.date.accessioned2014-01-27T17:22:57Z
dc.date.available2014-01-27T17:22:57Z
dc.date.issued2013
dc.description.abstractThehydromethanolic extract of Sapindus saponaria L. aerial parts was investigated for antimicrobial activity (against several Grampositive and Gram-negative bacteria and fungi) and capacity to inhibit the growth of different human tumor cell lines as also nontumor liver cells. The evaluated extract was further characterized in terms of phytochemicals using UV, 1H-NMR, 13C-NMR, and MS spectroscopic tools. The extract has shown a significant antimicrobial activity on all tested bacterial and fungal species. The best activity was achieved against Bacillus cereus and Staphylococcus aureus among bacteria and against all three Penicillium species tested. It also revealed cytotoxicity against human colon (HCT-15), cervical (HeLa), breast (MCF-7), and lung (NCI-H460) carcinoma cell lines, with HeLa being the most susceptible tumor cell line. The extract was not toxic for nontumor liver cells. Chromatographic separation of the extract resulted in the isolation and identification of stigmasterol, oleanolic acid, luteolin, luteolin 8-𝐶- β -glucoside (orientin), luteolin 6-𝐶- β -glucoside (isoorientin), luteolin 7-𝑂- β -glucuronide, and rutin. The results of the present findings may be useful for the discovery of novel antitumor and antimicrobial agents from plant origin.por
dc.identifier.citationRashed, Khaled N.; Ciric, Ana; Glamočlija, Jasmina; Calhelha, Ricardo C.; Ferrreira, Isabel C.F.R.; Sokovic, Marina (2013). Antimicrobial activity, growth inhibition of human tumor cell lines and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts. BioMed Research International. ISSN 2314-6133. 2013, p. 1-9por
dc.identifier.doi10.1155/2013/659183
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10198/9181
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHindawipor
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationTOWARD ANTIOXIDANT AND ANTITUMOR PROPERTIES OF WILD MEDICINAL PLANTS TRADITIONALLY USED IN PORTUGAL: EXTRACTS, ISOLATED FLAVONOIDS, AND THEIR HUMAN METABOLITES OBTAINED BY CHEMICAL SYNTHESIS
dc.titleAntimicrobial activity, growth inhibition of human tumor cell lines and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts.por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleTOWARD ANTIOXIDANT AND ANTITUMOR PROPERTIES OF WILD MEDICINAL PLANTS TRADITIONALLY USED IN PORTUGAL: EXTRACTS, ISOLATED FLAVONOIDS, AND THEIR HUMAN METABOLITES OBTAINED BY CHEMICAL SYNTHESIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F78307%2F2011/PT
oaire.citation.endPage9por
oaire.citation.startPage1por
oaire.citation.titleBioMed Research Internationalpor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublication9134dbb0-de49-421e-85a6-58e85f8eaaad
relation.isProjectOfPublication.latestForDiscoveryc59f09d4-9931-4f2e-babb-ef8bed998be7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Artigo 180.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus