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Antibiofilm potential of medicinal plants against Candida spp. oral biofilms: a review

2021Journal article Open access
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dc.contributor.authorGuimarães, Rafaela
dc.contributor.authorMilho, Catarina
dc.contributor.authorLiberal, Ângela
dc.contributor.authorSilva, Jani
dc.contributor.authorFonseca, Carmélia
dc.contributor.authorBarbosa, Ana Carolina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorAlves, Maria José
dc.contributor.authorBarros, Lillian
dc.date.accessioned2021-10-11T14:35:07Z
dc.date.available2021-10-11T14:35:07Z
dc.date.issued2021
dc.description.abstractThe use of natural products to promote health is as old as human civilization. In recent years, the perception of natural products derived from plants as abundant sources of biologically active compounds has driven their exploitation towards the search for new chemical products that can lead to further pharmaceutical formulations. Candida fungi, being opportunistic pathogens, increase their virulence by acquiring resistance to conventional antimicrobials, triggering diseases, especially in immunosuppressed hosts. They are also pointed to as the main pathogens responsible for most fungal infections of the oral cavity. This increased resistance to conventional synthetic antimicrobials has driven the search for new molecules present in plant extracts, which have been widely explored as alternative agents in the prevention and treatment of infections. This review aims to provide a critical view and scope of the in vitro antimicrobial and antibiofilm activity of several medicinal plants, revealing species with inhibition/reduction effects on the biofilm formed by Candida spp. in the oral cavity. The most promising plant extracts in fighting oral biofilm, given their high capacity to reduce it to low concentrations were the essential oils extracted from Allium sativum L., Cinnamomum zeylanicum Blume. and Cymbopogon citratus (DC) Stapf.pt_PT
dc.description.sponsorshipThe authors wish to acknowledge financial support from the project “AquaValor—Centro de Valorização e Transferência de Tecnologia da Água” (NORTE-01-0246-FEDER-000053), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); and L. Barros is grateful for her contract through the institutional scientific employment program-contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGuimarães, Rafaela; Milho, Catarina; Liberal, Ângela; Silva, Jani; Fonseca, Carmélia; Barbosa, Ana; Ferreira, Isabel C.F.R.; Alves, Maria José; Barros, Lillian (2021). Antibiofilm potential of medicinal plants against Candida spp. oral biofilms: a review. Antibiotics. ISSN 2079-6382. 10:9, p. 1-17pt_PT
dc.identifier.doi10.3390/antibiotics10091142pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10198/23984
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCandida spp.pt_PT
dc.subjectOral diseasept_PT
dc.subjectOral biofilmpt_PT
dc.subjectInfectionspt_PT
dc.subjectMedicinal plantspt_PT
dc.subjectPlant extractspt_PT
dc.subjectNatural compoundspt_PT
dc.subjectAntibiofilm strategiespt_PT
dc.titleAntibiofilm potential of medicinal plants against Candida spp. oral biofilms: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1142pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLiberal
person.familyNameFerreira
person.familyNameAlves
person.familyNameBarros
person.givenNameÂngela
person.givenNameIsabel C.F.R.
person.givenNameMaria José
person.givenNameLillian
person.identifier144781
person.identifier469085
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person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9764-4894
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridE-8500-2013
person.identifier.ridM-6624-2016
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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