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Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations

2020Journal article Open access
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dc.contributor.authorMiranda, Cristiane Grella
dc.contributor.authorSantos, Priscila Dayane Freitas dos
dc.contributor.authorSilva, Jéssica Thaís do Prado
dc.contributor.authorLeimann, Fernanda Vitória
dc.contributor.authorBorges, Bianca Ferreira
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorIneu, Rafael P.
dc.contributor.authorGonçalves, Odinei Hess
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T17:07:53Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T17:07:53Z
dc.date.issued2020
dc.description.abstractLutein is a bioactive found in dark leafy vegetables that may be used as a nutraceutical agent in foodstuff and an inhibitor of key enzymes of the human body such as those involved in the cholinergic system. However, its high hydrophobicity leads to low bioavailability and must be overcome if lutein is to be added in foods. The objective of this study was to evaluate the influence of nanoencapsulated lutein in the activity of the acetylcholinesterase enzyme. The in vitro study was carried out using water in order to evaluate the impact of encapsulation on the hydrophilicity of lutein. In vitro assays showed that lutein, both free and nanoencapsulated, presented a mixedtype inhibition behavior, and encapsulated lutein was able to inhibit acetylcholinesterase activity even in an aqueous medium. Inhibition was also showed by the in silico docking results which show that lutein interacted with the pocket region of the enzyme.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationGrella Miranda, Cristiane; dos Santos, Priscila Dayane Freitas; do Prado Silva, Jéssica Thaís; Vitória Leimann, Fernanda; Ferreira Borges, Bianca; Miguel Abreu, Rui; Porto Ineu, Rafael; Hess Gonçalves, Odinei (2020). Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations. Food Chemistry. ISSN 0308-8146. 307, p.en_EN
dc.identifier.doi10.1016/j.foodchem.2019.125523en_EN
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10198/15711
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationundefined
dc.subjectBioactiveen_EN
dc.subjectCholinergic hypothesisen_EN
dc.subjectEncapsulationen_EN
dc.subjectNanotechnologyen_EN
dc.subjectNutraceuticalen_EN
dc.titleInfluence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulationsen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameLeimann
person.familyNameAbreu
person.familyNameGonçalves
person.givenNameFernanda Vitória
person.givenNameRui M.V.
person.givenNameOdinei Hess
person.identifier.ciencia-id8F10-A04D-FC0D
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.orcid0000-0001-6230-9597
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0002-9528-8187
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id9335958400
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublicationb1102a0b-38dc-4caa-baed-ad52ccd9b230
relation.isAuthorOfPublicationcadb03a4-5e60-4745-b35f-fc3a97c071bc
relation.isAuthorOfPublication84c8eea0-77bb-4c18-b9d8-46f865980706
relation.isAuthorOfPublication.latestForDiscovery84c8eea0-77bb-4c18-b9d8-46f865980706

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