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Signatures of selection in the Iberian honey bee (Apis mellifera iberiensis) revealed by a genome scan analysis of single nucleotide polymorphisms (SNPs)

2013Journal article Open access
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dc.contributor.authorChávez-Galarza, Julio
dc.contributor.authorHenriques, Dora
dc.contributor.authorJohnston, J. Spencer
dc.contributor.authorAzevedo, João
dc.contributor.authorPatton, John C.
dc.contributor.authorMuñoz, Irene
dc.contributor.authorDe la Rúa, Pilar
dc.contributor.authorPinto, M. Alice
dc.date.accessioned2014-06-02T16:35:31Z
dc.date.available2014-06-02T16:35:31Z
dc.date.issued2013
dc.description.abstractUnderstanding the genetic mechanisms of adaptive population divergence is one of the most fundamental endeavours in evolutionary biology and is becoming increasingly important as it will allow predictions about how organisms will respond to global environmental crisis. This is particularly important for the honey bee, a species of unquestionable ecological and economical importance that has been exposed to increasing human-mediated selection pressures. Here, we conducted a single nucleotide polymorphism (SNP)-based genome scan in honey bees collected across an environmental gradient in Iberia and used four FST-based outlier tests to identify genomic regions exhibiting signatures of selection. Additionally, we analysed associations between genetic and environmental data for the identification of factors that might be correlated or act as selective pressures. With these approaches, 4.4% (17 of 383) of outlier loci were cross-validated by four FST-based methods, and 8.9% (34 of 383) were cross-validated by at least three methods. Of the 34 outliers, 15 were found to be strongly associated with one or more environmental variables. Further support for selection, provided by functional genomic information, was particularly compelling for SNP outliers mapped to different genes putatively involved in the same function such as vision, xenobiotic detoxification and innate immune response. This study enabled a more rigorous consideration of selection as the underlying cause of diversity patterns in Iberian honey bees, representing an important first step towards the identification of polymorphisms implicated in local adaptation and possibly in response to recent human-mediated environmental changes.por
dc.identifier.citationChávez-Galarza, Júlio; Henriques, Dora; Johnston, J. Spencer; Azevedo, João; Patton, John C.; Muñoz, Irene; De la Rúa, Pilar; Pinto, M. Alice (2013). Signatures of selection in the Iberian honey bee (Apis mellifera iberiensis) revealed by a genome scan analysis of single nucleotide polymorphisms (SNPs). Molecular Ecology. ISSN 1365-294X. 22:23, p. 5890–5907por
dc.identifier.doi10.1111/mec.12537
dc.identifier.issn1365-294X
dc.identifier.urihttp://hdl.handle.net/10198/9627
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relationPOPULATION GENOMICS AND LANDSCAPE GENETICS OF THE IBERIAN HONEY BEE APIS MELLIFERA IBERIENSIS
dc.subjectHoneypor
dc.subjectSelectionpor
dc.subjectSNPspor
dc.subjectIberian Peninsulapor
dc.titleSignatures of selection in the Iberian honey bee (Apis mellifera iberiensis) revealed by a genome scan analysis of single nucleotide polymorphisms (SNPs)por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePOPULATION GENOMICS AND LANDSCAPE GENETICS OF THE IBERIAN HONEY BEE APIS MELLIFERA IBERIENSIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F68682%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FBIA-BEC%2F099640%2F2008/PT
oaire.citation.endPage5907por
oaire.citation.startPage5890por
oaire.citation.titleMolecular Ecologypor
oaire.citation.volume22por
oaire.fundingStream5876-PPCDTI
person.familyNameHenriques
person.familyNameAzevedo
person.familyNamePinto
person.givenNameDora
person.givenNameJoão C.
person.givenNameMaria Alice
person.identifier.ciencia-id291F-986F-07DA
person.identifier.ciencia-id3F1F-0829-5878
person.identifier.ciencia-idF814-A1D0-8318
person.identifier.orcid0000-0001-7530-682X
person.identifier.orcid0000-0002-3061-8261
person.identifier.orcid0000-0001-9663-8399
person.identifier.scopus-author-id55761737300
person.identifier.scopus-author-id8085507800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd2abd09f-a90c-4cfb-9a60-7fc32f56184d
relation.isAuthorOfPublicatione15b0e75-689e-4be0-942c-1958cfefdb0f
relation.isAuthorOfPublication0667fe04-7078-483d-9198-56d167b19bc5
relation.isAuthorOfPublication.latestForDiscoveryd2abd09f-a90c-4cfb-9a60-7fc32f56184d
relation.isProjectOfPublication3f79b629-25f2-4565-8654-9478f4d32dc7
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