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Effect of chaethomellic acid on renal function in rat model of chronic renal failure

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dc.contributor.authorNogueira, António José M.
dc.contributor.authorMega, Carmén
dc.contributor.authorFonte, Elizabete
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorColaço, Bruno Jorge
dc.contributor.authorLópez-Novoa, Jose
dc.contributor.authorColaço, Aura
dc.contributor.authorPires, Maria João
dc.date.accessioned2014-09-25T13:29:54Z
dc.date.available2014-09-25T13:29:54Z
dc.date.issued2013
dc.description.abstractTo study the effect of chronic treatment with chaethomellic acid (CA), a highly specific inhibitor of ras farnesyl-protein transferase, on the renal function of rats with renal failure induced by renal mass reduction. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been placed in four experimental groups: RMR: rats without treat- ment (n=13); RMR+CA: rats treated with CA (n=13); SO: rats without treatment (n=13); SO+AC: rats treated with CA (n=13). CA was intraperitoneally administered in a dose of 0.23 g/Kg three times a week for 6 months. Creatinine, blood urea nitrogen (BUN) and protein were measured in serum and/or urine by routine laboratory techniques. BUN, creatinine, and proteinuria were significantly lower and creatinine clearance was significantly higher in SO and SO+AC groups when compared with RMR and RMR+AC groups. There were no differ- ences in creatinine, proteinuria and creatinine clearance between RMR and RMR+AC groups. Anyway, RMR+AC group showed significant lower BUN and lower creatinine and proteinuria, and higher creatinine clearance than RMR group. In a model of renal failure induced by RMR, 6 months of treatment with CA may have some beneficial effect on renal function.por
dc.identifier.citationNogueira, António José M.; Mega, Carmén; Fonte, Elizabete; Oliveira, Paula; Colaço, Bruno; López-Novoa, Jose; Colaço, Aura; Pires, Maria (2013). Effect of chaethomellic acid on renal function in rat model of chronic renal failure. Virchows Archiv. ISSN 0945-6317. 463:2; p. 297-297por
dc.identifier.issn0945-6317
dc.identifier.urihttp://hdl.handle.net/10198/10600
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.subjectRatpor
dc.subjectKidneypor
dc.titleEffect of chaethomellic acid on renal function in rat model of chronic renal failurepor
dc.typeconference paper
dspace.entity.typePublication
oaire.citation.endPage297por
oaire.citation.startPage297por
oaire.citation.titleVirchows Archicpor
oaire.citation.volume463por
person.familyNameNogueira
person.givenNameAntónio José M.
person.identifier.ciencia-id8A11-794E-36BD
person.identifier.orcid0000-0001-8912-7355
person.identifier.scopus-author-id55865568268
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication648209a2-eec9-4bec-975a-32673e41b95c
relation.isAuthorOfPublication.latestForDiscovery648209a2-eec9-4bec-975a-32673e41b95c

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