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Aesculus hippocastanum L.: a simple ornamental plant or a source of compelling molecules for industry?

2023Journal article Open access
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dc.contributor.authorDridi, Asma
dc.contributor.authorReis, Filipa S.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorPereira, Carla
dc.contributor.authorZaghdoudi, Khalil
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorBarreira, João C.M.
dc.date.accessioned2022-01-21T14:21:50Z
dc.date.available2022-01-21T14:21:50Z
dc.date.issued2023
dc.description.abstractAesculus hippocastanum L., also known as horse chestnut, is an ornamental tree whose seeds are mostly discarded in landfills in the regions where they are grown. However, recent studies have shown that these seeds can be a source of interesting compounds for several industries. This work aimed to chemically characterize horse chestnut seeds at the level of compounds recognized for their wide bioactivity, i.e., organic acids, including phenolic compounds, using chromatographic methodologies (UFLC-DAD and LC-DAD-ESI/MSn). In addition, the bioactivity of these seeds was evaluated by in vitro methodologies, seeking to relate the respective (bio)activity to the compounds present in the endocarp (husk), seed coat (skin), and peeled seed (pulp). The antioxidant activity (lipid peroxidation inhibition and oxidative haemolysis inhibition), antibacterial potential (against Gram-positive and Gram-negative bacteria) and cytotoxicity (in human tumour cell lines and porcine liver primary cells) were evaluated. Kaempferol-O-pentoside-O-hexoside-O-hexoside was the main phenolic identified in the pulp. At the same time, (-)-epicatechin and beta-type (epi)catechin dimer were the major phenolics present in husk and skin, respectively. In general, A. hippocastanum extracts presented antioxidant and antibacterial potential, without toxicity up to the maximal tested dose. Overall, these findings anticipate potential applications of A. hippocastanum seeds in food- or pharmaceutical-related uses.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDridi, Asma; Reis, Filipa S.; Pires, Tânia C.S.P.; Calhelha, Ricardo C.; Pereira, Carla; Zaghdoudi, Khalil; Ferreira, Isabel C.F.R.; Barros, Lillian; Barreira, João C.M. (2023). Aesculus hippocastanum L.: a simple ornamental plant or a source of compelling molecules for industry?. Separations. eISSN 2297-8739. 10:3, p. 1-14pt_PT
dc.identifier.doi10.3390/separations10030160
dc.identifier.eissn2297-8739
dc.identifier.urihttp://hdl.handle.net/10198/24829
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHorse chestnutpt_PT
dc.subjectAnalytical techniques
dc.subjectChromatographic methodologies
dc.subjectBioactive compounds
dc.subjectBioactivity
dc.subjectIndustrial applications
dc.titleAesculus hippocastanum L.: a simple ornamental plant or a source of compelling molecules for industry?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleSeparationspt_PT
person.familyNameReis
person.familyNamePires
person.familyNameCalhelha
person.familyNamePereira
person.familyNameFerreira
person.familyNameBarros
person.familyNameBarreira
person.givenNameFilipa S.
person.givenNameTânia C.S.P.
person.givenNameRicardo C.
person.givenNameCarla
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.givenNameJoão C.M.
person.identifier2118829
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person.identifier.scopus-author-id36982144400
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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