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Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores.

2011Conference object Open access
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dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorFroufe, Hugo J.C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorQueiroz, Maria João R.P.
dc.date.accessioned2011-08-31T10:23:25Z
dc.date.available2011-08-31T10:23:25Z
dc.date.issued2011
dc.description.abstractAngiogenesis is the process of new blood vessel formation from pre-existing vascular networks by capillary sprouting, and plays an important role in the pathogenesis of several disorders including cancer, proliferative retinopathies and rheumatoid arthritis. A key regulatory pathway of angiogenesis is mediated by the vascular endothelial growth factor (VEGF) and its cell membrane tyrosine kinase receptor VEGFR-2 (also know as KDR kinase) [1]. Several VEGFR-2 inhibitors have emerged as promising anti-angiogenic agents for possible treatment against a wide variety of cancers including: sorafenib, sunitinib, and pazopanib, that have been approved for the treatment of advanced renal cell carcinoma. Several scaffolds have been studied for anti-VEGFR-2 activity as thieno[3,2-b]pyridines [2].por
dc.identifier.citationAbreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P. (2011). Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores. In XII Encontro Nacional da Sociedade Portuguesa de Química: 100 anos de Química em Portugal. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/6082
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/PROTEC/49450/2009
dc.titleRational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores.por
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FQUI-QUI%2F111060%2F2009/PT
oaire.citation.conferencePlaceBragapor
oaire.citation.titleXII Encontro Nacional da Sociedade Portuguesa de Química- 100 anos de Química em Portugal, 3 a 6 de Julho de 2011por
oaire.fundingStream5876-PPCDTI
person.familyNameAbreu
person.familyNameFerreira
person.givenNameRui M.V.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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