Repository logo
 
Publication

Pyridyl-functionalized and surface molecularly imprinted cellulose particles to target bioactive compounds in olive leaf

2025Journal article Embargoed access
Simple item page
datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAlmeida, Ayssata Patrícia da Costa Leocádia Vaz
dc.contributor.authorGaspar, Rita M.
dc.contributor.authorFerreira-Dias, Suzana
dc.contributor.authorCosta, Mário Rui
dc.contributor.authorDias, Rolando
dc.date.accessioned2025-06-02T08:21:45Z
dc.date.available2025-06-02T08:21:45Z
dc.date.issued2025
dc.description.abstractHybrid particles consisting of a cellulose core and a 4-vinylpyridine-based cross-linked shell were synthesized inthe presence of the quercetin imprinting template by surface initiated atom transfer radical polymerization (ATRP). The modification of cellulose with the introduction of pyridyl moieties was demonstrated by FTIR, SEM, surface area measurement and quantification of nitrogen in the hybrid particles by elemental analysis. The hybrid materials were assessed for their sorption capacity for standard polyphenols under competitive binding and considering different solvents. It was demonstrated that they exhibited a strong binding capacity for these types of molecules due to favorable interactions with the pyridyl nitrogen, even when loading hydro- alcoholic solvents with high alcohol content (e.g. ethanol/water 80/20 v/v) was employed. Adsorbent particles synthesized at the gram scale were packed into HPLC columns, demonstrating their ability to be used in continuous separation processes and the reusability of the materials. Cycling of the packed column with a solvent gradient was performed without observation of a too high backpressure (maximum value observed ~15 bar). Two different industrial olive leaf extracts, characterized by their high polyphenol and triterpene content, were purified by sorption/desorption using the hybrid adsorbent particles. The present study demonstrates that hybrid particles allow the separation of target compounds in olive leaf. Using simple sorption/desorption steps, enrichment factors of about 20 for glycosylated flavonoids and 6 for luteolin were measured with the two olive leaf extracts.eng
dc.description.sponsorshipThe authors acknowledge the support through the OLEAF4VALUE project. This project had received funding from the Bio-Based Industries Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 101023256. The authors also thank NATAC for providing the olive leaf extracts and the aid with the identification by LC-MS of compounds there contained. Rolando Dias is grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). Mário Rui Costa acknowledges the support by LA/P/0045/2020 (ALiCE), UIDB/50020/2020, and UIDP/ 50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC).
dc.identifier.citationAlmeida, Ayssata; Gaspar, Rita M.; Ferreira-Dias, Suzana; Costa, Mário Rui P.F.N.; Dias, Rolando (2025). Pyridyl-functionalized and surface molecularly imprinted cellulose particles to target bioactive compounds in olive leaf. Reactive and Functional Polymers. ISSN 1381-5148. 214, p. 1-17
dc.identifier.doi10.1016/j.reactfunctpolym.2025.106338
dc.identifier.issn1381-5148
dc.identifier.urihttp://hdl.handle.net/10198/34526
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relation.ispartofReactive and Functional Polymers
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCellulose
dc.subjectFunctionalization
dc.subjectPyridyl
dc.subjectAdsorbents
dc.subjectCircular bioeconomy
dc.titlePyridyl-functionalized and surface molecularly imprinted cellulose particles to target bioactive compounds in olive leafeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.citation.endPage17
oaire.citation.startPage1
oaire.citation.titleReactive and Functional Polymers
oaire.citation.volume214
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876-PPCDTI
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.givenNameRolando
person.identifier.ciencia-id8417-4D84-973B
person.identifier.orcid0000-0001-7369-382X
person.identifier.ridM-8552-2013
person.identifier.scopus-author-id7102885104
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationd7109687-6adf-4268-a462-8d1a2e2c01cb
relation.isAuthorOfPublication.latestForDiscoveryd7109687-6adf-4268-a462-8d1a2e2c01cb
relation.isProjectOfPublication29718e93-4989-42bb-bcbc-4daff3870b25
relation.isProjectOfPublication0aac8939-28c2-46f4-ab6b-439dba7f9942
relation.isProjectOfPublication6255046e-bc79-4b82-8884-8b52074b4384
relation.isProjectOfPublication79ed495f-40dc-45d0-b98c-7e777db59e9b
relation.isProjectOfPublication75d8d4f7-ae07-4777-a9f1-3e833d96d5b4
relation.isProjectOfPublication59db4b60-8cc2-4f07-a25a-8cfe78f2778f
relation.isProjectOfPublication.latestForDiscovery29718e93-4989-42bb-bcbc-4daff3870b25

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1-s2.0-S1381514825001907-main.pdf
Size:
6.97 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus