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The influence of Castanea sativa Mill. flower extract on hormonally and chemically induced prostate cancer in a rat model

2021Journal article Open access
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dc.contributor.authorNascimento-Gonçalves, Elisabete
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorSilva, Marcelo Aparecido de Souza
dc.contributor.authorFardilha, Margarida
dc.contributor.authorFerreira, Rita
dc.contributor.authorNeuparth, Maria João
dc.contributor.authorFaustino-Rocha, Ana
dc.contributor.authorColaço, B.
dc.contributor.authorVenâncio, Carlos
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorOliveira, Mónica M.F.
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorRosa, Eduardo
dc.contributor.authorOliveira, Paula A.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-23T12:12:53Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-23T12:12:53Z
dc.date.issued2021
dc.description.abstractProstate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and antioxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PCa. Forty male Wistar Unilever rats were randomly assigned to four groups: control, induced, control + CF, and induced + CF groups. Animals from the induced groups were exposed to a multistep protocol for PCa induction. The CF extract, rich in trigalloyl-HHDP-glucoside and obtained via decoction, was administered to the CF groups in drinking water (3 mg per animal per day) for 49 weeks. Animals were sacrificed at 61 weeks of age. Regarding the effects of CFs on dorsolateral prostate tumorigenesis, no significant differences were observed between the induced and induced + CF groups. However, animals exposed to the CF extract showed fewer inflammation areas on the dorsolateral prostate lobe than those not exposed to CF. Moreover, the CF extract alleviated the hepatic oxidative stress associated with the multistep protocol, resulting in lower levels of lipid peroxidation. These results suggest that CF extract has antioxidant and anti-inflammatory properties. This journal is.en_EN
dc.description.sponsorshipThis work was supported by European Investment Funds by FEDER/COMPETE/POCI - Operational Competitiveness and Internationalization and National Funds by FCT - Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (CITAB), UIDB/00690/2020 (CIMO), UIDB/50006/2020 (LAQV), UIDB/CVT/00772/2020 (CECAV), and UIDP/00616/2020 (CQ-VR), the project RUNawayPCa (POCI-01-0145- FEDER-016728 and PTDC/DTP-DES/6077/2014), and PhD fellowship SFRH/BD/136747/2018. L. Barros also acknowledges national funding by FCT, P.I., through the institutional scientific employment program-contract for her contract. The Interreg Program received financial support from the Project IBERPHENOL, Project Number 0377_IBERPHENOL_6_E, cofinanced by the European Regional Development Fund (ERDF) through POCTEP 2014-2020.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationNascimento-Gonçalves, E.; Seixas, F.; Silva, M.; Fardilha, M.; Ferreira, R.; Neuparth, M. J.; Faustino-Rocha, A. I.; Colaço, B.; Venâncio, C.; Barros, L.; Ferreira, I. C.F.R.; Oliveira, M. M.; Peixoto, F.; Rosa, E.; Oliveira, P. A. (2021). The influence of Castanea sativa Mill. flower extract on hormonally and chemically induced prostate cancer in a rat model. Food and Function. ISSN 2042-6496. 12:6, p. 2631-2643en_EN
dc.identifier.doi10.1039/d1fo00029ben_EN
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/24379
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationVeterinary and Animal Science Research Centre
dc.relationMountain Research Center
dc.relationChemistry Center - Vila Real
dc.relationRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
dc.relationalterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
dc.titleThe influence of Castanea sativa Mill. flower extract on hormonally and chemically induced prostate cancer in a rat modelen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleMountain Research Center
oaire.awardTitleChemistry Center - Vila Real
oaire.awardTitleRUNNING away from prostate cancer: WALKING through the molecular basis of physical activity
oaire.awardTitlealterado para: “Contribuição para o estudo do cancro da próstata: influência do estilo de vida num modelo animal Contribution to the study of prostate cancer: lifestyle influence in an animal model”. Estudo do impacto da atividade física no microambiente do cancro da próstata num modelo animal
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00616%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FDTP-DES%2F6077%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F136747%2F2018/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamFARH
person.familyNameBarros
person.familyNameFerreira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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