Publication
New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies
| dc.contributor.author | Abreu, Rui M.V. | |
| dc.contributor.author | Queiroz, Maria João R.P. | |
| dc.contributor.author | Ferreira, Isabel C.F.R. | |
| dc.contributor.author | Calhelha, Ricardo C. | |
| dc.contributor.author | Adega, Filomena | |
| dc.contributor.author | Chaves, Raquel | |
| dc.date.accessioned | 2011-08-18T14:35:42Z | |
| dc.date.available | 2011-08-18T14:35:42Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide [1]. HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed. Sorafenib was the first approved small molecule against HCC and underlines the importance of identifying potential new anti-HCC drugs [2]. Thirty-two 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates, previously prepared by some of us [3,4], were evaluated as potential new anti-HCC agents by studying their in vitro cell growth inhibition on human HepG2 cells, generally regarded as a good HCC model, and hepatotoxicity using a porcine liver primary cell culture (PLP1). The presence of amino groups linked to a benzene moiety on the substituent of the 6-position emerged as the key element for the anti-HCC activity. | por |
| dc.identifier.citation | Abreu, Rui M.V.; Queiroz, Maria-João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Adega, Filomena; Chaves, Raquel (2011). New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies. In XX Porto Cancer Meeting. Drug resistance in cancer: from biology to molecular targets and drugs. Porto | por |
| dc.identifier.uri | http://hdl.handle.net/10198/6008 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.relation | SFRH/PROTEC/49450/2009 | |
| dc.title | New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies | por |
| dc.type | conference object | |
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| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT | |
| oaire.citation.conferencePlace | Porto | por |
| oaire.citation.title | XX Porto Cancer Meeting. Drug resistance in cancer: from biology to molecular targets and drugs, 28 e 29 de Abril de 2011 | por |
| oaire.fundingStream | 5876-PPCDTI | |
| oaire.fundingStream | SFRH | |
| person.familyName | Abreu | |
| person.familyName | Ferreira | |
| person.familyName | Calhelha | |
| person.givenName | Rui M.V. | |
| person.givenName | Isabel C.F.R. | |
| person.givenName | Ricardo C. | |
| person.identifier | 144781 | |
| person.identifier.ciencia-id | 0F19-0DE2-12A2 | |
| person.identifier.ciencia-id | 9418-CF95-9919 | |
| person.identifier.ciencia-id | F313-E3CE-554E | |
| person.identifier.orcid | 0000-0002-7745-8015 | |
| person.identifier.orcid | 0000-0003-4910-4882 | |
| person.identifier.orcid | 0000-0002-6801-4578 | |
| person.identifier.rid | E-8500-2013 | |
| person.identifier.rid | J-2172-2014 | |
| person.identifier.scopus-author-id | 7003290613 | |
| person.identifier.scopus-author-id | 36868826600 | |
| person.identifier.scopus-author-id | 6507978333 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
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