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Transglutaminases: recent achievements and new sources

dc.contributor.authorMartins, Ivone
dc.contributor.authorMatos, Mauro
dc.contributor.authorCosta, Rodrigo Arthur Fonseca
dc.contributor.authorSilva, Fátima H.
dc.contributor.authorPascoal, Ananias
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorChoupina, Altino
dc.date.accessioned2014-09-24T14:34:03Z
dc.date.available2014-09-24T14:34:03Z
dc.date.issued2014
dc.description.abstractTransglutaminases are a family of enzymes (EC 2.3.2.13), widely distributed in various organs, tissues, and body fluids, that catalyze the formation of a covalent bond between a free amine group and the γ-carboxamide group of protein or peptide-bound glutamine. Besides forming these bonds, that exhibit high resistance to proteolytic degradation, transglutaminases also form extensively cross-linked, generally insoluble, protein biopolymers that are indispensable for the organism to create barriers and stable structures. The extremely high cost of transglutaminase of animal origin has hampered its wider application and has initiated efforts to find an enzyme of microbial origin. Since the early 1990s, many microbial transglutaminase-producing strains have been found, and production processes have been optimized. This has resulted in a rapidly increasing number of applications of transglutaminase in the food sector. However, applications of microbial transglutaminase in other sectors have also been explored, but in a much lesser extent. Our group has identified a transglutaminase in the oomycete Phytophthora cinnamomi, which is able to induct defense responses and disease-like symptoms. In this mini-review, we report the achievements in this area in order to illustrate the importance and the versatility of transglutaminases.por
dc.identifier.citationMartins, Ivone; Matos, Mauro; Costa, Rodrigo; Silva, Fátima; Pascoal, Ananias; Estevinho, Leticia M.; Choupina, Altino (2014). Transglutaminases: recent achievements and new sources. Applied Microbiology and Biotechnology. ISSN 0175-7598. 98:16, p. 6957-6964por
dc.identifier.doi10.1007/s00253-014-5894-1
dc.identifier.issn0175-7598
dc.identifier.urihttp://hdl.handle.net/10198/10578
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.subjectTransglutaminasepor
dc.subjectMTGpor
dc.subjectPhytophthora cinnamomipor
dc.subjectApplicationspor
dc.titleTransglutaminases: recent achievements and new sourcespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6964por
oaire.citation.issue16por
oaire.citation.startPage6957por
oaire.citation.titleApplied Microbiology and Biotechnologypor
oaire.citation.volume98por
person.familyNamePascoal
person.familyNameEstevinho
person.familyNameChoupina
person.givenNameAnanias
person.givenNameLetícia M.
person.givenNameAltino
person.identifier587972
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.ciencia-id1A14-77FC-9656
person.identifier.orcid0000-0003-3823-0402
person.identifier.orcid0000-0002-9249-1948
person.identifier.orcid0000-0002-3956-9398
person.identifier.ridL-5382-2014
person.identifier.scopus-author-id23486345000
person.identifier.scopus-author-id6506577664
person.identifier.scopus-author-id14051602500
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd18ce2ea-5f83-459f-b9c0-921c14c7c6dd
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication314b895b-a5e2-4a92-9bc6-dd708c819be4
relation.isAuthorOfPublication.latestForDiscovery314b895b-a5e2-4a92-9bc6-dd708c819be4

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