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Development of a cosmetic anti-aging gel formulation with extracts of spontaneous plants and cultivars of Humulus lupulus L.

2021Conference object Open access
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dc.contributor.authorSantos, Briolanja
dc.contributor.authorPereira, Olívia R.
dc.contributor.authorAfonso, Andrea Luísa Fernandes
dc.contributor.authorPedro, Luís G.
dc.contributor.authorCardoso, Susana M.
dc.contributor.authorSousa, Maria João
dc.date.accessioned2021-03-03T10:11:57Z
dc.date.available2021-03-03T10:11:57Z
dc.date.issued2021
dc.description.abstractHop (Humulus lupulus L.) is known worldwide as an essential flavor in the beer industry. Its major compounds have been demonstrated to be associated to health benefits, due to its antimicrobial, antioxidant, anti-inflammatory and anticancer activities [1]. This study intended to develop and to evaluate the stability of an anti-aging cosmetic gel by incorporation of different percentages of hydroalcoholic extracts obtained from cones (flowers) and vegetative parts (leaves) of hop spontaneous and of the Cascade and Polaris cultivars and essential oil of Thymus zygis. In addition, the phytochemical profile and antimicrobial activities determination of hop extracts and of essential oil of thymus were performed. A methylcellulose gel formulation was used as base to develop the hop cosmetic product. Subsequently, several parameters were evaluated to address its physical-chemical stability. In addition to that, the phenolic profile of hop extracts was determined by UHPLC-DAD-ESI-MS2 [2] while the composition of thyme essential oil was done by GC and GC-MS. The ability to inhibit the microbial growth was performed by microdilution broth method and the diffusion in agar test. Contrary to hop extracts, thyme oil has shown to exert antibacterial and antifungal activities and thus, it was added to the formulation as preservative. Carvacrol, terpinen-4-ol and p-cimene, determined as major compounds in this oil, could be important contributors for these activities. The extracts obtained from hop cones were rich in phenolic compounds such as cohumulone, humulone and xanthohumol, which have been claimed as possessing anti-wrinkle effect [3]. Concerning stability of the formulations, no phase separation was observed in the centrifugation, mechanical vibration tests or the color tests. However, changes were observed in the UV-Visible spectra between 300nm to 350nm wavelengths, probably by presence of the phenolic compounds such as example xanthohumol, cohumulona, humulona and lupulona [3]. In texture by back extrusion, only the formulation with the extracts of the Polaris variety has high consistency and low viscosity. In the light test there was phase separation in the samples due to the occurrence of dehydration, to minimize this effect, it must be properly in a non-transparent packaging to protect from light. Overall, the incorporation of hydroalcoholic extracts of hop and essential oil of thyme in methylcellulose gel formulations, especially with Polaris variety with 2.5% hydroalcoholic extract of hop cones, allow to obtained a stable cosmetic with potential as anti-aging take into account the chemical composition.pt_PT
dc.description.sponsorshipThanks to FCT (Portugal) and the ERDF under the PT2020 Program for financial support to CIMO (UIDB/00690/2020) and LAQV-REQUIMTE (UIDB/50006/2020). SMC acknowledges the research contract (project AgroForWealth, CENTRO-01-0145-FEDER-000001).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBriolanja, Santos; Pereira, Olívia R.; Afonso, Andrea F.; Pedro, Luís; Cardoso, Susana M.; Sousa, Maria João (2021). Development of a cosmetic anti-aging gel formulation with extracts of spontaneous plants and cultivars of Humulus lupulus L. In 1st Natural products application: health, cosmetic and food: livro de resumos. ISBN 978-972-745-286-6pt_PT
dc.identifier.isbn978-972-745-286-6
dc.identifier.urihttp://hdl.handle.net/10198/23444
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstituto Politécnico de Bragançapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHop extractspt_PT
dc.subjectEssential oilpt_PT
dc.subjectHumulus lupulus L.pt_PT
dc.subjectCosmeticpt_PT
dc.subjectGelpt_PT
dc.subjectAnti-agingpt_PT
dc.subjectChemical compositionpt_PT
dc.titleDevelopment of a cosmetic anti-aging gel formulation with extracts of spontaneous plants and cultivars of Humulus lupulus L.pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceOnlinept_PT
oaire.citation.startPage257pt_PT
oaire.citation.title1st Natural products application: Health, Cosmetic and Foodpt_PT
person.familyNameSantos
person.familyNamePereira
person.familyNameAfonso
person.familyNameSousa
person.givenNameBriolanja
person.givenNameOlívia R.
person.givenNameAndrea Luísa Fernandes
person.givenNameMaria João
person.identifier145216
person.identifier.ciencia-id2F19-F5E7-0D03
person.identifier.ciencia-idB312-AF21-D2FA
person.identifier.ciencia-id9C1D-41E7-9BBF
person.identifier.ciencia-idD91E-3571-3979
person.identifier.orcid0000-0003-1535-682X
person.identifier.orcid0000-0002-6275-3134
person.identifier.orcid0000-0002-8858-1617
person.identifier.orcid0000-0002-9946-4926
person.identifier.ridH-1049-2014
person.identifier.scopus-author-id52264387000
person.identifier.scopus-author-id36766901000
person.identifier.scopus-author-id55230282700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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