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Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

2015Journal article Open access
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dc.contributor.authorPereira, Carla
dc.contributor.authorBarreira, João C.M.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorLopes, Mélissa
dc.contributor.authorQueiroz, Maria João R.P.
dc.contributor.authorVilas-Boas, Miguel
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-10-21T09:38:14Z
dc.date.available2015-10-21T09:38:14Z
dc.date.issued2015
dc.description.abstractDue to the enormous variety of phytochemicals present in plants, their extracts have been used for centuries in the treatment of innumerable diseases, being perceived as an invaluable source of medicines for humans. Furthermore, the combination of different plants was reported as inducing an improved effect (synergism) in comparison with the additive activity of the plants present in those mixtures. Nevertheless, information regarding the effects of plant infusions added with honey is still rather scarce. Accordingly, the aim of this study was to evaluate the interaction between chestnut honey, a natural product with well-reported beneficial properties, and three medicinal plants (either as a single plant or as combinations of two and three plants), with regard to their antioxidant activity and hepatotoxicity. Antioxidant activity was evaluated by comparing the results from four different assays; hepatotoxicity was assessed in two different cell lines. Results were compared by analysis of variance and linear discriminant analysis. The addition of honey to the infusions had a beneficial result in both cases, producing a synergistic effect in all samples, except β-carotene bleaching inhibition for artichoke + milk thistle + honey preparation and also preparations with lower hepatotoxicity, except in the case of artichoke + honey. Moreover, from the discriminant linear analysis output, it became obvious that the effect of honey addition overcame that resulting from using single plant or mixed plant based infusions. Also, the enhanced antioxidant activity of infusions containing honey was confirmed by lower hepatotoxicity.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011) and L. Barros researcher contract under “Programa Compromisso com Ciência – 2008”.pt_PT
dc.identifier10.1039/c4fo01206b
dc.identifier.citationPereira, Carla; Barreira, João C.M.; Calhelha, Ricardo C.; Lopes, Melissa; Queiroz, Maria João R.P.; Vilas-Boas, Miguel; Barros, Lillian; Ferreira, Isabel C.F.R. (2015). Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects? Food & Function. ISSN 2042-6496. 6:5, p. 1435-1442pt_PT
dc.identifier.doi10.1039/c4fo01206b
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/12171
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationStrategic Project - UI 690 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleIs honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage1442pt_PT
oaire.citation.startPage1435pt_PT
oaire.citation.titleFood & Functionpt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePereira
person.familyNameBarreira
person.familyNameCalhelha
person.familyNameVilas-Boas
person.familyNameBarros
person.familyNameFerreira
person.givenNameCarla
person.givenNameJoão C.M.
person.givenNameRicardo C.
person.givenNameMiguel
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier1415151
person.identifier1693134
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridK-1629-2016
person.identifier.ridD-8269-2013
person.identifier.ridJ-2172-2014
person.identifier.ridI-5949-2013
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person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id54895546900
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person.identifier.scopus-author-id6602648497
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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