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Activity of phenolic compounds from plant origin against Candida species

2015Journal article Open access
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dc.contributor.authorMartins, Natália
dc.contributor.authorBarros, Lillian
dc.contributor.authorHenriques, Mariana
dc.contributor.authorSilva, Sónia
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-26T09:50:27Z
dc.date.available2015-11-26T09:50:27Z
dc.date.issued2015
dc.description.abstractCandida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.pt_PT
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012), L. Barros researcher contract under “Programa Compromisso com Ciência – 2008” and financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011). This work was also supported by the Programa Operacional, Fatores de competitividade – COMPETE and by national funds through FCT – Fundação para a Ciência e a Tecnologia on the scope of the projects FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012 and PEst-OE/EQB/LA0023/2013. The authors thank the Project “BioHealth - Biotechnology and Bioengineering approaches to improve health quality", Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER.pt_PT
dc.identifier10.1016/j.indcrop.2015.05.067
dc.identifier.citationMartins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R. (2015). Activity of phenolic compounds from plant origin against Candida species. Industrial Crops and Products. ISSN 0926-6690. 74, p. 648-670pt_PT
dc.identifier.doi10.1016/j.indcrop.2015.05.067pt_PT
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/12427
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMechanisms of Candida glabrata biofilms tolerance to antifungal agents
dc.relationConsolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB
dc.relationPLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
dc.relationStrategic Project - UI 690 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhytochemicalspt_PT
dc.subjectPlant extractspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntifungal activitypt_PT
dc.subjectCandida speciespt_PT
dc.titleActivity of phenolic compounds from plant origin against Candida speciespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMechanisms of Candida glabrata biofilms tolerance to antifungal agents
oaire.awardTitleConsolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB
oaire.awardTitlePLANTAS MEDICINAIS A UTILIZAR EM FITOTERAPIA COMO ANTI-FÚNGICOS: EFEITO DE COMPOSTOS FENÓLICOS NO CRESCIMENTO DE ESPÉCIES DE CANDIDA EM SUSPENSÃO E EM BIOFILMES
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-MIC%2F119069%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/RECI%2FBBB-EBI%2F0179%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Incentivo%2FEQB%2FLA0023%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87658%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage670pt_PT
oaire.citation.startPage648pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume74pt_PT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.familyNameFerreira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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