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Wild mushroom extracts as inhibitors of bacterial biofilm formation

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dc.contributor.authorAlves, Maria José
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorLourenço, Inês
dc.contributor.authorCosta, Eduardo Manuel
dc.contributor.authorMartins, Anabela
dc.contributor.authorPintado, Manuela
dc.date.accessioned2015-10-29T11:40:02Z
dc.date.available2015-10-29T11:40:02Z
dc.date.issued2014
dc.description.abstractIntroduction: Microorganisms can colonize a wide variety of medical devices, putting patients in risk for local and systemic infectious complications. These microorganisms are able to grow adhered to almost every surface, forming biofilms. The use of natural products has been successful in the discovery of new medicine, and mushrooms could be a source of natural antimicrobials. Objectives: The present study reports the capacity of wild mushroom extracts to inhibit in vitro biofilm formation by multi-resistant bacteria. Methods: Four Gram-negative bacteria biofilm producers (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Acinetobacter baumannii) isolated from urine were used to verify the activity of Russula delica, Fistulina hepatica, Mycena rosea, Leucopaxilus giganteus and Lepista nuda extracts. Results: The results obtained showed that all tested mushroom extracts presented some extent of inhibition of biofilm production. Pseudomonas aeruginosa was the microorganism with the highest capacity of biofilm production, being also the most susceptible to the extracts inhibition capacity (≥ 50%). Among the five tested extracts against E. coli, Leucopaxillus giganteus (47.8%) and Mycenas rosea (44.8%) presented the highest inhibition of bio lm formation. The extracts exhibiting the highest inhibitory effect upon P. mirabilis biofilm formation were Sarcodon imbricatus (45.4%) and Russula delica (53.1%). Acinetobacter baumannii was the microorganism with the lowest susceptibility to mushroom extracts inhibitory effect on biofilm production. Conclusions: This is a pioneer study since, as far as we know, there are no reports on the inhibition of biofilm production by the studied mushroom extracts and in particular against multi-resistant clinical isolates.pt_PT
dc.identifier.citationAlves, Maria José; Ferreira, Isabel C.F.R.; Lourenço, Inês; Costa, Eduardo; Martins, Anabela; Pintado, Manuela (2014). Wild mushroom extracts as inhibitors of bacterial biofilm formation. In 2nd World Congress of Health Research. Viseupt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12220
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectClinical isolatespt_PT
dc.subjectBiofilmpt_PT
dc.subjectMushroom extractspt_PT
dc.titleWild mushroom extracts as inhibitors of bacterial biofilm formationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.title2nd World Congress of Health Research. Viseu- Portugal, 7-8 October 2014. Aten Primaria. 2014;46(Espec Cong 1):51pt_PT
person.familyNameAlves
person.familyNameFerreira
person.familyNameMartins
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.givenNameAnabela
person.identifier144781
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-6218-4413
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.ridG-5488-2013
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7203013518
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication383370dd-10e5-40e6-9a15-f2201fe95581
relation.isAuthorOfPublication.latestForDiscovery383370dd-10e5-40e6-9a15-f2201fe95581

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