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Insights into the chemical composition and in vitro bioactive properties of mangosteen (Garcinia mangostana L.) pericarp

2023Journal article Open access
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dc.contributor.authorAlbuquerque, Bianca R.
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPinela, José
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorAlves, Maria José
dc.contributor.authorCorrêa, Rúbia C.G.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorBarros, Lillian
dc.date.accessioned2011-05-04T10:59:38Z
dc.date.available2011-05-04T10:59:38Z
dc.date.issued2023
dc.description.abstractThe industrial processing of mangosteen (Garcinia mangostana L.) generates high amounts of waste, as similar to 60% of the fruit is formed by an inedible pericarp. However, its pericarp has been explored as a source of xanthones; nevertheless, studies addressing the recovery of other chemical compounds from such biomass are still scarce. Hence, this study intended to elucidate the chemical composition of the mangosteen pericarp, including fat-soluble (tocopherols and fatty acids) and water-soluble (organic acids and phenolic compound non-xanthones) compounds present in the following extracts: hydroethanolic (MT80), ethanolic (MTE), and aqueous (MTW). In addition, the antioxidant, anti-inflammatory, antiproliferative and antibacterial potentials of the extracts were assessed. The mangosteen pericarp showed a composition with seven organic acids, three tocopherol isomers, four fatty acids and fifteen phenolic compounds. Regarding the extraction of phenolics, the MT80 was the most efficient (54 mg/g extract), followed by MTE (19.79 mg/g extract) and MTW (4.011 mg/g extract). All extracts showed antioxidant and antibacterial activities; however, MT80 and MTE extracts were more efficient than MTW. Only MTW did not show anti-inflammatory properties, whereas MTE and MT80 showed inhibitory activities towards tumor cell lines. Notwithstanding, MTE showed cytotoxicity towards normal cells. Our findings support the idea that the ripe mangosteen pericarp is a source of bioactive compounds, although their recovery is dependent on the extraction solvent.por
dc.identifier.citationAlbuquerque, Bianca R.; Dias, Maria Inês; Pinela, José; Calhelha, Ricardo C.; Pires, Tânia C.S.P.; Alves, Maria José; Corrêa, Rúbia C.G.; Ferreira, Isabel C.F.R.; Oliveira, M. Beatriz P. P.; Barros, Lillian (2023). Insights into the chemical composition and in vitro bioactive properties of mangosteen (Garcinia mangostana L.) pericarp. Foods. eISSN 2304-8158. 12:5, p. 1-15por
dc.identifier.doi10.3390/foods12050994
dc.identifier.eissn2304-8158
dc.identifier.urihttp://hdl.handle.net/10198/4158
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.subjectFood waste recovery
dc.subjectBioactive compounds
dc.subjectFlavonoids
dc.subjectAntiproliferative activity
dc.subjectFood supplement
dc.titleInsights into the chemical composition and in vitro bioactive properties of mangosteen (Garcinia mangostana L.) pericarppor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFoodspor
person.familyNameAlbuquerque
person.familyNameDias
person.familyNamePinela
person.familyNameCalhelha
person.familyNamePires
person.familyNameAlves
person.familyNameCorrêa
person.familyNameFerreira
person.familyNameBarros
person.givenNameBianca R.
person.givenNameMaria Inês
person.givenNameJosé
person.givenNameRicardo C.
person.givenNameTânia C.S.P.
person.givenNameMaria José
person.givenNameRúbia C.G.
person.givenNameIsabel C.F.R.
person.givenNameLillian
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rcaap.rightsopenAccesspor
rcaap.typearticlepor
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