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Advisor(s)
Abstract(s)
Vitamin E, a lipophilic natural antioxidant comprising different vitamers (α, β, γ and δ-tocopherols and tocotrianols), is frequently used in food supplements and added in different products, such as foodstuffs and cosmetics, to prevent lipid oxidation processes. Due to solubility and stability issues, α-tocopherol is generally administrated as succinate or acetate derivatives, which have lower bioavailability. In this work, alginate microspheres containing α-tocopherol were produced and evaluated for encapsulation efficiency and release profiles at different pH conditions during 24h. In vitro release tests showed that alginate microspheres maintain its integrity under simulated gastric conditions. By the contrary, under simulated intestinal conditions, an almost complete release is achieved during 24h, with a major portion (70%) being released after 2h.
Description
Keywords
Citation
Vieira, D.; Amaral, J.S.; Barreiro, M.F. (2014). Study of the encapsulation efficiency and release profiles of alginate microspheres containing α-tocopherol. In 12th International Chemical and Biological Engineering Conference. Porto. ISBN 978-972-752-170-8
Publisher
FEUP edições