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The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects

2016Journal article Open access
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dc.contributor.authorCampos, Jaqueline Ferreira
dc.contributor.authorCastro, David Tsuyoshi Hiramatsu
dc.contributor.authorDamião, Marcio José
dc.contributor.authorTorquato, Heron F. Vieira
dc.contributor.authorParedes-Gamero, Edgar Julian
dc.contributor.authorCarollo, Carlos Alexandre
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authorSantos, Edson Lucas dos
dc.date.accessioned2018-01-31T10:00:00Z
dc.date.accessioned2018-01-31T15:40:42Z
dc.date.available2018-01-31T10:00:00Z
dc.date.available2018-01-31T15:40:42Z
dc.date.issued2016
dc.description.abstractNatural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells. The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract's inhibition of AAPH-induced lipid peroxidation in human erythrocytes. Its cytotoxicity and possible mechanisms of action were assessed in Jurkat and K562 leukemic cell lines. The ethanol extract contained flavonoids, such as epigallocatechin, epicatechin, kaempferol heteroside, rutin, and dimeric and trimeric proanthocyanidin derivatives. The extract exhibited antioxidant activity by scavenging free radicals and antihemolytic action, and it decreased malondialdehyde content in human erythrocytes. Furthermore, the extract also induced leukemic cell death by activating intracellular calcium and caspase-3, decreasing mitochondrial membrane potential, and arresting the cell cycle in S and G2 phases. Hence, S. velutina leaf extract contains antioxidant and antileukemic biomolecules with potential applications in diseases associated with oxidative stress and in the inhibition of tumor cell proliferation.en_EN
dc.description.sponsorshipThis work was supported by grants of the Fundac¸˜ao de Apoio ao Desenvolvimento do Ensino, Ciˆencia e Tecnologia do Mato Grosso do Sul (FUNDECT), Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnol´ogico (CNPq), and Coordenac¸˜ao de Aperfeic¸oamento de Pessoal de N´ıvel Superior (CAPES). Edson Lucas dos Santos, Carlos Alexandre Carollo, and Edgar J. Paredes-Gamero are recipients of fellowships from Brazilian National Research Council (CNPq), Brazil.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationCampos, Jaqueline Ferreira; Castro, David Tsuyoshi Hiramatsu; Damiaõ, Marcio José; Torquato, Heron F. Vieira; Paredes-Gamero, Edgar J.; Carollo, Carlos Alexandre; Estevinho, Leticia M.; Souza, Kely de Picoli; Santos, Edson Lucas (2016). The Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effects. Oxidative Medicine and Cellular Longevity. ISSN 1942-0900. p. 1-13en_EN
dc.identifier.doi10.1155/2016/8405957en_EN
dc.identifier.issn1942-0900
dc.identifier.urihttp://hdl.handle.net/10198/15373
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titleThe Chemical Profile of Senna velutina Leaves and Their Antioxidant and Cytotoxic Effectsen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameEstevinho
person.givenNameLetícia M.
person.identifier.ciencia-idBA14-09D6-A406
person.identifier.orcid0000-0002-9249-1948
person.identifier.scopus-author-id6506577664
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication4a1d5ba2-1854-4ca5-89a4-73f35e964df9
relation.isAuthorOfPublication.latestForDiscovery4a1d5ba2-1854-4ca5-89a4-73f35e964df9

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