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2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure–activity relationship study

2010Journal article Open access
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dc.contributor.authorSantos, Clementina M.M.
dc.contributor.authorFreitas, Marisa
dc.contributor.authorRibeiro, Daniela
dc.contributor.authorGomes, Ana Sara
dc.contributor.authorSilva, Artur
dc.contributor.authorCavaleiro, José
dc.contributor.authorFernandes, Eduarda
dc.date.accessioned2011-02-02T16:24:49Z
dc.date.available2011-02-02T16:24:49Z
dc.date.issued2010
dc.description.abstractXanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main goal of this work was to evaluate the scavenging activity of the new 2,3-diarylxanthones for ROS, including superoxide radical (O2 ), hydrogen peroxide (H2O2), singlet oxygen (1O2), peroxyl radical (ROO ) and hypochlorous acid (HOCl), and RNS, including nitric oxide ( NO) and peroxynitrite anion (ONOO ). The obtained results revealed that the tested 2,3-diarylxanthones are endowed with outstanding ROS and RNS scavenging properties, considering the nanomolar to micromolar range of the IC50 values found. The xanthones with two catechol rings were the most potent scavengers of all tested ROS and RNS. In conclusion, the new 2,3-diarylxanthones are promising molecules to be used for their potential antioxidant properties.por
dc.identifier.citationSantos, Clementina; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda (2010). 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18:18, p. 6776-6784por
dc.identifier.doi10.1016/j.bmc.2010.07.044
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10198/3241
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subject2,3-Diarylxanthonespor
dc.subjectReactive oxygen speciespor
dc.subjectReactive nitrogen speciespor
dc.subjectScavenging activitypor
dc.subjectAntioxidant activitypor
dc.title2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure–activity relationship studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6784por
oaire.citation.startPage6776por
oaire.citation.titleBioorganic and Medicinal Chemistrypor
person.familyNameSantos
person.givenNameClementina M.M.
person.identifier.ciencia-id9018-DB9C-C590
person.identifier.orcid0000-0003-4380-7990
person.identifier.scopus-author-id7201458663
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64f662b6-775d-4ea0-bfd7-f527af0ac1a0
relation.isAuthorOfPublication.latestForDiscovery64f662b6-775d-4ea0-bfd7-f527af0ac1a0

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