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A study on the medicinal mushroom Cordyceps militaris (L.) link: chemical characterization, antioxidant, antimicrobial and antiproliferative properties

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dc.contributor.authorReis, Filipa S.
dc.contributor.authorStojković, Dejan
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorĆirić, Ana
dc.contributor.authorVan Griensven, Leo J.L.D.
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2013-09-09T10:56:32Z
dc.date.available2013-09-09T10:56:32Z
dc.date.issued2013
dc.description.abstractThe Cordyceps genus is well known for its medicinal properties. A number of bioactive constituents from Cordyceps species have been reported such as antibacterial, antifungal, immunopotentiating or antitumor agents [1]. The anti-inflammatory and anti-angiogenic properties of Cordyceps militaris (L.) Link have been reported as also the antioxidant activity of its cultured mycelium [2]. In this work, the chemical characterization of C. militaris was performed, includingbioactive compounds (free sugars, unsaturated fatty acids, tocopherols, organic acidsand phenolic compounds). The antioxidant potential of its methanolic extract was evaluated (reducing power, scavenging activity and lipid peroxidationinhibition) as also the antimicrobial activity (tested towards Gram positive and Gram negative bacteria and eight microfungi) and antiproliferative properties (tested in different human tumor cell lines). Mannitol and trehalose were the main free sugars found in this species (2.01 and 24.71 g/100 g dw, respectively). The fatty acid quantified in higher amounts was linoleic acid (68.00% of total fatty acids). a-Tocopherol was the only isoform of vitam in E detected (55.86 j.lg/1 00 g dw). The organic acids found in this mushroom were oxalic (0.33 g/1 00 g dw), citric (7.97 g/1 00 g dw) and fumaric (0 .1 3 g/100 g dw) acids. p-Hydroxybenzoic acid was the only phenolic acid quantified in C. militaris (0.02 mg/1 00 g dw), but cinnamic acid was also found (0. 11 mg/1 00 g dw). The lowest EC50 values for the antioxidant potential were presented in lipid peroxidation inhibition assays, namely in 13-carotene/l inoleate and TBARS assays (1.05 mg/ml and 0. 77 mg/ml, respectively). The methanolic extract also revealed strong antibacterial and antifungal activities, and it was able to inhibit the proliferation of MCF-7 (breast}, NCI-H460 (non-smalllung),HCT-15 (colon) and Hela (cervical) human carcinoma cell lines.por
dc.description.sponsorshipFCT (Portugal) and COMPETE/QREN/EU: projects PTOC/AGR-ALI/110062/2009 and PEstOE/AGR/UI0690/2011, and to Serbian Ministry of Education and Science for financial support (grant number 173032).por
dc.identifier.citationReis, Filipa S.; Stojković, Dejan; Glamočlija, Jasmina; Ćirić, Ana; van Griensven, Leo J.I.D.; Soković, Marina; Ferreira, Isabel C.F.R. (2013). A study on the medicinal mushroom Cordyceps militaris (L.) Link: chemical characterization, antioxidant, antimicrobial and antiproliferative properties. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8670
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPEstOE/AGR/UI0690/2011
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.titleA study on the medicinal mushroom Cordyceps militaris (L.) link: chemical characterization, antioxidant, antimicrobial and antiproliferative propertiespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream5876-PPCDTI
person.familyNameReis
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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