A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives

Carocho, Márcio; Ferreira, Isabel C.F.R.

Publication

A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives

2013Journal article

dc.contributor.author	Carocho, Márcio
dc.contributor.author	Ferreira, Isabel C.F.R.
dc.date.accessioned	2013-07-23T16:38:13Z
dc.date.available	2013-07-23T16:38:13Z
dc.date.issued	2013
dc.description.abstract	Many studies have been conducted with regard to free radicals, oxidative stress and antioxidant activity of food, giving antioxidants a prominent beneficial role, but, recently many authors have questioned their importance, whilst trying to understand the mechanisms behind oxidative stress. Many scientists defend that regardless of the quantity of ingested antioxidants, the absorption is very limited, and that in some cases prooxidants are beneficial to human health. The detection of antioxidant activity as well as specific antioxidant compounds can be carried out with a large number of different assays, all of them with advantages and disadvantages. The controversy around antioxidant in vivo benefits has become intense in the past few decades and the present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies. It also identifies the limitations of antioxidants and provides a perspective on the likely future trends in this field.	por
dc.description.sponsorship	Fundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011).	por
dc.identifier.citation	Carocho, Márcio; Ferreira, Isabel C.F.R. (2013). A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food and Chemical Toxicology. ISSN 0278-6915. 51, p. 15-25	por
dc.identifier.doi	10.1016/j.fct2012.09.021
dc.identifier.issn	0278-6915
dc.identifier.uri	http://hdl.handle.net/10198/8534
dc.language.iso	eng	por
dc.peerreviewed	yes	por
dc.publisher	Elsevier	por
dc.relation	Strategic Project - UI 690 - 2011-2012
dc.subject	Free radicals	por
dc.subject	Oxidative stress	por
dc.subject	Antioxidants	por
dc.subject	Prooxidants	por
dc.subject	Future perspectives	por
dc.title	A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives	por
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Strategic Project - UI 690 - 2011-2012
oaire.awardURI	info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.citation.endPage	25	por
oaire.citation.startPage	15	por
oaire.citation.title	Food and Chemical Toxicology	por
oaire.citation.volume	51	por
oaire.fundingStream	6817 - DCRRNI ID
person.familyName	Carocho
person.familyName	Ferreira
person.givenName	Márcio
person.givenName	Isabel C.F.R.
person.identifier	awbWiiMAAAAJ&hl
person.identifier	144781
person.identifier.ciencia-id	5614-005B-5CF1
person.identifier.ciencia-id	9418-CF95-9919
person.identifier.orcid	0000-0002-8978-4547
person.identifier.orcid	0000-0003-4910-4882
person.identifier.rid	E-8500-2013
person.identifier.scopus-author-id	52463229800
person.identifier.scopus-author-id	36868826600
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	por
rcaap.type	article	por
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