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Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves

2018Journal article Open access
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dc.contributor.authorRached, Wahiba
dc.contributor.authorZeghada, Fatima Zohra
dc.contributor.authorBennaceur, Malika
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorAlves, Maria José
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorMarouf, Abderrazak
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2019-01-28T11:48:45Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2019-01-28T11:48:45Z
dc.date.issued2018
dc.description.abstractTetraclinis is an unexplored genus recognized for its great bioactive potential that could be explored as a medicinal herb. The aim of this study was to evaluate the antioxidant, antibacterial, anti-inflammatory and cytotoxic properties of the aqueous crude extract and subsequent organic fractions of the Algerian medicinal plant T. articulata. Moreover, polyphenols were also fully profiled by liquid chromatography with diode-array detection coupled to electrospray ionization in tandem with mass spectrometry (LC–DAD–ESI–MSn). The analysis of the obtained results show that B-type (epi)catechin dimer and catechin were the most abundant phenolic compounds present among the nine different flavonoids identified such as: ((epi)catechin, myricetin, quercetin and kaempferol glycoside derivatives). The concentration of phenolic compounds in the ethyl acetate fraction (93.1 mg/g extract) was higher than the one of the aqueous extract (21.2 mg/g extract) and butanol fraction (43.87 mg/g extract). Furthermore, the ethyl acetate fraction revealed the strongest bioactive properties, revealing the lowest EC50/GI50 values: anti-inflammatory (EC50 129.67 μg/mL), cytotoxicity against human tumor cell lines (GI50, 59–189 μg/mL), antibacterial (MIC, 0.625–10 mg/mL); and especially the antioxidant capacity (EC50 values lower than 12.7 μg/mL), even higher than the standard (Trolox). The results showed a great bioactive potential for this species, with a significant contribution of flavonoid compounds, which makes it an interesting matrix in the development of novel pharmaceutical formulations.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationRached, Wahiba; Zeghada, Fatima Zohra; Bennaceur, Malika; Barros, Lillian; Calhelha, Ricardo C.; Heleno, Sandrina; Alves, Maria José; Carvalho, Ana Maria; Marouf, Abderrazak; Ferreira, Isabel C.F.R. (2018) - Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves. Industrial Crops and Products. ISSN 0926-6690. 112, p. 460-466en_EN
dc.identifier.doi10.1016/j.indcrop.2017.12.037en_EN
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/18556
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationObtaining of mycosterols to develop new functionalized foods: extraction, refinement, stabilization and incorporation into dairy products
dc.subjectAnti-inflammatoryen_EN
dc.subjectAntibacterialen_EN
dc.subjectAntioxidanten_EN
dc.subjectCytotoxicityen_EN
dc.subjectPhenolic compoundsen_EN
dc.subjectTetraclinis articulataen_EN
dc.titlePhytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leavesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleObtaining of mycosterols to develop new functionalized foods: extraction, refinement, stabilization and incorporation into dairy products
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F101413%2F2014/PT
oaire.fundingStream5876
person.familyNameBarros
person.familyNameCalhelha
person.familyNameHeleno
person.familyNameAlves
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameSandrina A.
person.givenNameMaria José
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
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person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridL-5951-2014
person.identifier.ridM-6624-2016
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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