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Tracing the path between mushrooms and Alzheimer's disease-a literature review

2023Artigo científico Acesso aberto
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dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorPreto, Marco
dc.contributor.authorGrosso, Clara
dc.contributor.authorVieira, Monica
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorVasconcelos, Vítor
dc.contributor.authorReis, Mariana
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Rosario
dc.date.accessioned2018-03-09T15:21:51Z
dc.date.available2018-03-09T15:21:51Z
dc.date.issued2023
dc.description.abstractAlzheimer's disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only two drugs are close to being able to halt its progression. For decades, natural compounds produced by living organisms have been at the forefront of research for new therapies. Mushrooms, which are well-known for their nutritional and medicinal properties, have also been studied for their potential use in the treatment of AD. Natural products derived from mushrooms have shown to be beneficial in several AD-related mechanisms, including the inhibition of acetylcholinesterase (AChE) and & beta;-secretase (BACE 1); the prevention of amyloid beta (A & beta;) aggregation and neurotoxicity; and the prevention of Tau expression and aggregation, as well as antioxidant and anti-inflammatory potential. Several studies in the literature relate mushrooms to neurodegenerative diseases. However, to the best of our knowledge, there is no publication that summarizes only AD data. In this context, this review aims to link the therapeutic potential of mushrooms to AD by compiling the anti-AD potential of different mushroom extracts or isolated compounds, targeting known AD-related mechanisms.pt_PT
dc.description.sponsorshipThis work is funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project GreenHealth—digital strategies in biological assets to improve well-being and promote green health, Norte-01-0145-FEDER-000042.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, Ana Margarida; Preto, Marco; Grosso, Clara; Vieira, Monica; Delerue-Matos, Cristina; Vasconcelos, Vítor; Reis, Mariana; Barros, Lillian; Martins, Rosario (2023). Tracing the path between mushrooms and Alzheimer's disease-a literature review. Molecules. eISSN 1420-3049. 28:14, p. 1-28pt_PT
dc.identifier.doi10.3390/molecules28145614
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10198/16245
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMushroomspt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectNatural productspt_PT
dc.subjectTherapypt_PT
dc.titleTracing the path between mushrooms and Alzheimer's disease-a literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMoleculespt_PT
person.familyNameBarros
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01

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