Repository logo
 
Publication

Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate

2016Journal article Open access
Simple item page
dc.contributor.authorRaposo, Claudia
dc.contributor.authorPetrova, Krasimira T.
dc.contributor.authorBarros, M. Teresa
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorSoković, Marina
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2016-12-22T16:02:17Z
dc.date.available2016-12-22T16:02:17Z
dc.date.issued2016
dc.description.abstractSucrose octa(N-ethyl)carbamate was synthesized directly from sucrose and ethyl isocyanate, and its structure was confirmed by various analytical methods, such as 1H and 13C NMR, FTIR, m.p., MS, and optical rotation. Its antibacterial, antifungal and cytotoxic activities were investigated. It exhibited strong inhibition against all bacteria tested, namely S. aureus (MIC 0.18±0.006), B. cereus (MIC 0.094±0.000), M. flavus (MIC 0.28±0.01), L. monocytogenes (MIC 0.18±0.006), P. aeruginosa (MIC 0.094±0.002), S. typhimurium (MIC 0.094±0.002), E. coli (MIC 0.18±0.006) and E. cloacae (MIC 0.18±0.006) and strong antifungal activity towards T. viride (MIC 0.09 ± 0.006), A. versicolor (MIC 0.18 ± 0.01), A. ochraceus (MIC 0.375 ± 0.01) and P. ochrochloron (MIC 0.375 ± 0.04). Furthermore, it showed moderate antitumor potential against human breast (GI50357.20±14.12), colon (GI50 332.43±11.19) and cervical (GI50 282.67±3.97) cell lines and, more important, without hepatotoxicity.pt_PT
dc.description.sponsorshipThis work has been supported by Fundação para a Ciência e a Tecnologia through grants No. PEst- C/EQB/LA0006/2013 and PEst-OE/AGR/UI0690/2011. The authors thank to Serbian Ministry of Education and Science for financial support (grant No. 173032). The NMR spectrometers are part of The National NMR Facility, supported by Fundação para a Ciência e a Tecnologia (RECI/BBBBQB/ 0230/2012).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRaposo, Claudia; Petrova, Krasimira T.; Barros, M. Teresa; Calhelha, Ricardo C.; Soković, Marina; Ferreira, Isabel C.F.R. (2016). Synthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamate. Medicinal Chemistry. ISSN 1573-4064. 12:1, p. 22-29pt_PT
dc.identifier.doi10.2174/1573406410666150807111029pt_PT
dc.identifier.issn1573-4064
dc.identifier.urihttp://hdl.handle.net/10198/13647
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationNMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiological activitypt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectCytotoxic activitypt_PT
dc.subjectCarbamatept_PT
dc.subjectCarbohydratespt_PT
dc.subjectMicrowave chemistry,pt_PT
dc.titleSynthesis, characterization, antimicrobial and antitumor activities of sucrose Octa(N-ethyl)carbamatept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleNMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FEQB%2FLA0006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FBBB-BQB%2F0230%2F2012/PT
oaire.citation.endPage29pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage22pt_PT
oaire.citation.titleMedicinal Chemistrypt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isProjectOfPublicationf7e58456-fee7-485f-8b49-d2c240945602
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublicationda3c5999-c4aa-42df-a506-70f15a140589
relation.isProjectOfPublication.latestForDiscoveryf7e58456-fee7-485f-8b49-d2c240945602

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Artigo+375.pdf
Size:
827.7 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus