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Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis model

2013Journal article Open access
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dc.contributor.authorBarreira, João C.M.
dc.contributor.authorCosta, Roberto Germano
dc.contributor.authorPombo, Graça
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-05-13T14:34:08Z
dc.date.available2014-05-13T14:34:08Z
dc.date.issued2013
dc.description.abstractGlycemic and lipidic profiles might be influenced by several factors. The fact that the age group might alter the most extensively evaluated lipidic and glycemic parameters is a more or less well accepted fact. To verify this empirical notion, 996 human subjects aged between 21 and 90 years from different localities were characterized according to age. To assess lipid profile, total cholesterol and cholesterol associated with lipoprotein fractions (c-LDL and c-HDL) and triglycerides were determined. Regarding glycemic profile, glucose and glycated hemoglobin were measured. The majority of the population had values of lipidic parameters fit into the reference values, presenting low or moderate risk for developing cardiovascular disease. Blood glucose was often far above the desirable, but this can be devalued due to the HbA1c values, which were overwhelmingly located in the normal range. The categorization of data in different age groups did not allow defining statistically significant differences. Despite the discriminant linear model was presented, the results indicate that age group did not act as a strong discriminant factor. Somehow unexpectedly, the most significant differences were found among the different localities, which tended to show a similarity according with their latitude. Furthermore, there were no significant correlations in the parameters associated with lipidic profile, but there was a direct correlation between glucose levels and HbA1c (glycemic parameters).por
dc.identifier.citationBarreira, João C.M.; Costa, Roberto; Pombo, M. Graça; Ferreira, Isabel C.F.R. (2013). Intersubject variability of blood analysis reference values: assessment of age and locality influence by means of a Linear Discriminant Analysis model. Journal of Clinical Laboratory Analysis. ISSN 1098-2825. 27:3, p. 237-244por
dc.identifier.doi10.1002/jcla.21590
dc.identifier.issn1098-2825
dc.identifier.urihttp://hdl.handle.net/10198/9506
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectLDL-Cpor
dc.subjectHDL-Cpor
dc.subjectTriglyceridespor
dc.subjectGlycated hemoglobinpor
dc.subjectBiostatisticspor
dc.titleIntersubject variability of blood analysis reference values: assessment of age and locality influence by means of a linear discriminant analysis modelpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage244por
oaire.citation.startPage237por
oaire.citation.titleJournal of Clinical Laboratory Analysispor
oaire.citation.volume27por
person.familyNameBarreira
person.familyNameFerreira
person.givenNameJoão C.M.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4629b12c-39b0-4da8-8b8d-6efba5cf2d81
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8

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