Repository logo
 
Publication

Leaves and decoction of Juglans regia L.: different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects

2013Journal article Open access
Simple item page
dc.contributor.authorSantos, André
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-05-14T11:22:35Z
dc.date.available2014-05-14T11:22:35Z
dc.date.issued2013
dc.description.abstractJuglans regia L. (walnut) leaves are considered a source of healthcare compounds, and have been widely used in traditional medicine. Furthermore, they have been reported as a source of bioactive molecules such as the antioxidant phenolic compounds. In the present study, organic acids, mono and oligosaccharides, and tocopherols were analyzed in leaves and decoction (widely used for topical applications). Furthermore, the phenolic composition and bioactivity of walnut leaves was determined in its decoction and methanol extract. Malic acid, sucrose, α-tocopherol and 3-O-caffeoylquinic acids and quercetin O-pentoside were the most abundant organic acid, disaccharide, tocopherol isomer and phenolic compounds, respectively. Methanol extract presented higher antioxidant and antitumor potential than decoction; both samples did not show toxicity for non-tumor liver primary cells. This study provides a more complete characterization of phenolic compounds of walnut leaves, and as far as we know, this is the first time that the presence of procyanidins and taxifolin derivatives, as also tocopherols were reported in J. regia leaves.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). L. Barros and R.C. Calhelha also thank to FCT, POPH-QREN and FSE for their grants (SFRH/BPD/4609/2008 and SFRH/BPD/68344/2010, respectively). The GIP-USAL is financially supported by the Spanish Government through the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063). M. Dueñas thanks the Programa Ramón y Cajal for a contract.por
dc.identifier.citationSantos, André; Barros, Lillian; Calhelha, Ricardo C.; Dueñas, Montserrat; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2013). Leaves and decoction of Juglans regia L.: different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects. Industrial Crops and Products. ISSN 0926-6690. 51, p. 430–436por
dc.identifier.doihttp://dx.doi.org/10.1016/j.indcrop.2013.10.003
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10198/9513
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
dc.subjectJuglans regia L.por
dc.subjectChemical characterizationpor
dc.subjectDecoction/methanol extractpor
dc.subjectAntioxidant propertiespor
dc.subjectAntitumor effectspor
dc.titleLeaves and decoction of Juglans regia L.: different performances regarding bioactive compounds and in vitro antioxidant and antitumor effectspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleNEW ANTITUMOR AND/OR ANTI-ANGIOGENIC HETEROCYCLIC COMPOUNDS: SYNTHESIS, MOLECULAR MODELLING AND INHIBITION ENZYMATIC ASSAYS USING TYROSINE KINASE MEMBRANE GROWTH FACTOR RECEPTORS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.endPage436por
oaire.citation.startPage430por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume51por
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameBarros
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifierID G-7399-2011
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-idD31A-35AF-E2A9
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublication977f5254-f7c5-4c91-873f-2700ecd4692f
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublicationb598cc70-fee0-491e-a33b-641bd0a20490
relation.isProjectOfPublication.latestForDiscoveryc59f09d4-9931-4f2e-babb-ef8bed998be7

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
J regia_ICP-Revised-1.pdf
Size:
581.22 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
1-s2.0-S0926669013005529-main.pdf
Size:
526.6 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus